20-HETE MaxSpec Standard | CAS:79551-86-3

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• 製品情報
• 製品詳細
• 文献

価格

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製品情報

20-HETE is a cytochrome P450 (CYP450) metabolite postulated to play an autacoid role in the renal and cerebral vasculature. In rat cerebral microvessels, 20-HETE is a vasoconstrictor that mediates pressure-induced autoregulatory vasoconstriction. 20-HETE is excreted mainly as the glucuronide conjugate. The concentration of free 20-HETE (20-40 pg/ml in human urine) is about 10-fold lower than the corresponding concentration of the 20-glucuronide. 20-HETE can be further metabolized by cyclooxygenase to 20-hydroxy PGG₂ and 20-hydroxy PGH₂.

20-HETE MaxSpec^® standard is a quantitative grade standard of 20-HETE (Item No. 90030) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently preparedcalibration standard. This 20-HETE MaxSpec^® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stabilitytesting is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

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製品詳細

name	20-HETE MaxSpec Standard
Formal Name	20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid
CAS Number	79551-86-3
Synonyms	20-hydroxy Arachidonic Acid
Molecular Formula	C20H32O3
Formula Weight	320.5
Purity	≥95%
Formulation	A solution in ethanol
SMILES	OCCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
Stability	≥ 1 year

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文献

1. McGiff, J.C., and Quilley, J. 20-HETE and the kidney: Resolution of old problems and new beginnings. Am. J. Physiol. 277(3 Pt 2), R607-R623 (1999).

2. Gebremedhin, D., Lange, A.R., Lowry, T.F., et al. Production of 20-HETE and its role in autoregulation of cerebral blood flow. Circ. Res. 87(1), 60-65 (2000).

3. Prakash, C., Zhang, J.Y., Falck, J.R., et al. 20-Hydroxyeicosatetraenoic acid is excreted as a glucuronide conjugate in human urine. Biochem. Biophys. Res. Commun. 185(2), 728-733 (1992).

4. Schwartzman, M.L., Falck, J.R., Yadagiri, P., et al. Metabolism of 20-hydroxyeicosatetraenoic acid by cyclooxygenase. Formation and identification of novel endothelium-dependent vasoconstrictor metabolites. J. Biol. Chem. 264(20), 11658-11662 (1989).

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