Leukotriene B4 MaxSpec Standard | CAS:71160-24-2

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• 製品情報
• 製品詳細
• 文献

価格

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製品情報

Leukotriene B₄ (LTB₄) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10⁻¹⁰ M), LTB₄ causes chemotaxis and chemokinesis in human polymorphonuclear leukocytes. At higher concentrations, (1.0 x 10⁻⁷ M), LTB₄ leads to neutrophil aggregation and degranulation as well as superoxide anion production.

LTB₄ MaxSpec^® standard is a quantitative grade standard of LTB₄ (Item No. 20110) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This LTB₄ MaxSpec^® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

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製品詳細

name	Leukotriene B4 MaxSpec Standard
Formal Name	5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid
CAS Number	71160-24-2
Synonyms	LTB4
Molecular Formula	C20H32O4
Formula Weight	336.5
Purity	≥95%
Formulation	A solution in ethanol
SMILES	CCCCC/C=C\C[C@@H](O)/C=C/C=C\C=C\[C@@H](O)CCCC(=O)O
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
Stability	≥ 1 year

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文献

1. Rådmark, O., Malmsten, C., Samuelsson, B., et al. Leukotriene A: Stereochemistry and enzymatic conversion to leukotriene B. Biochem. Biophys. Res. Commun. 92(3), 954-961 (1980).

2. Ford-Hutchinson, A.W., Bray, M.A., Doig, M.V., et al. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286(5770), 264-265 (1980).

3. McGee, J., and Fitzpatrick, F. Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes. J. Biol. Chem. 260(23), 12832-12837 (1985).

4. Ford-Hutchinson, A.W. Leukotriene B4 in inflammation. Crit. Rev. Immunol. 10(1), 1-12 (1990).

5. McMillan, R.M., and Foster, S.J. Leukotriene B4 and inflammatory disease. Agents Actions 24(1-2), 114-119 (1988).

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