Thromboxane B2 MaxSpec Standard | CAS:54397-85-2

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• 製品情報
• 製品詳細
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価格

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製品情報

Thromboxane B₂ (TXB₂) is a stable, biologically inert metabolite formed from the non-enzymatic hydrolysis of TXA₂, which has a half-life of about 30 seconds. Urinary analysis of TXB₂ accurately reflects intrarenal TXA₂ synthesis, while measurement of 11-dehydro and 2,3-dinor TX metabolites gives the best estimate of systemic TXA₂ secretion.

TXB₂ MaxSpec^® standard is a quantitative grade standard of TXB₂ (Item No. 19030) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed underargon. The concentration was verified by comparison to an independently prepared calibration standard. This TXB₂ MaxSpec^® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

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製品詳細

name	Thromboxane B2 MaxSpec Standard
Formal Name	9α,11,15S-trihydroxythromba-5Z,13E-dien-1-oic acid
CAS Number	54397-85-2
Synonyms	TXB2
Molecular Formula	C20H34O6
Formula Weight	370.5
Purity	≥95%
Formulation	A solution in methyl acetate
SMILES	CCCCCC(O)/C=C/[C@H]1OC(O)CC(O)C1C/C=C\CCCC(=O)O
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
Stability	≥ 1 year

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文献

1. Needleman, P., Moncada, S., Bunting, S., et al. Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides. Nature 261(5561), 558-560 (1976).

2. Patrono, C., Ciabattoni, G., Patrignani, P., et al. Evidence for a renal origin of urinary thromboxane B2 in health and disease. Adv. Prostaglandin Thromboxane Leukot. Res. 11, 493-498 (1983).

3. Lawson, J.A., Patrono, C., Ciabattoni, G., et al. Long-lived enzymatic metabolites of thromboxane B2 in the human circulation. Anal. Biochem. 155(1), 198-205 (1986).

4. Patrono, C., Ciabattoni, G., Pugliese, F., et al. Estimated rate of thromboxane secretion into the circulation of normal humans. J. Clin. Invest. 77(2), 590-594 (1986).

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