100th つないで、進む FRONTIERS IN LIFE SCIENCE

検索の使い方

Manumycin A (CAS: 52665-74-4)

掲載日情報：2018/09/26 現在Webページ番号：52367

アディポジェン ライフ サイエンシーズ /
Adipogen Life Sciences
[メーカー略称：KOM]

AdipoGen社のManumycin A (CAS: 52665-74-4)です。
AdipoGen社は高品質な低分子化合物、希少な抗生物質、天然物などを販売しています。生理活性や阻害効果を有する物質も多数取り揃えております。

※本製品は研究用です。研究用以外には使用できません。

カートに商品を
追加しました。

価格



目次に戻る

カートに商品を
追加しました。

製品情報

商品コードBVT-0091
品名Manumycin A
分子式C31H38N2O7
分子量550.6
CAS52665-74-4
構造式
純度≥96% (HPLC)
形状Yellow to brown powder.
別名-
特長
  • Antibiotic.
  • Apoptosis and endoplasmic reticulum stress-mediated cell death inducer.
  • Potent, selective and competitive cell permeable rasfarnesyltransferase inhibitor (IC50 = 30 nM).
  • Does not affect geranylgeranyltransferase (IC50 = 180 µM).
  • Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras.
  • Neutral sphingomyelinase inhibitor.
  • Blocks insulin-induced MAP kinase activation in rat cardiac myocytes (19 µM).
  • Targets protein phosphatase 1α (PP1α) and reduces hydrogen peroxide.
  • Corrects aberrant splicing of the muscle chloride channel Clcn1 in myotonic dystrophy type 1 (DM1).
  • Shows potential anti-inflammatory activity.
  • Irreversible human thioredoxin reductase 1 (TrxR-1) inhibitor (IC50=272nM) and inducer of NADPH oxidase activity. Acts very likely as a Michael acceptor to the nucleophilic Sec residue in the C-terminal redox center of TrxR-1 which yields a SecTRAP (selenium compromised thioredoxin reductase-derived apoptotic proteins), which promotes both apoptosis and necrosis via oxidative stress and increased intracellular reactive oxygen species (ROS) production. 
文献
  1. Identification of Rasfarnesyltransferase inhibitors by microbial screening: M. Hara et al.; PNAS 90, 2281 (1993)
  2. Inhibitors of Rasfarnesyltransferases: F. Tamanoi; TIBS 18, 349 (1993), (Review)
  3. Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic: J.B. Gibbs, et al.; Cell 77, 175 (1994)
  4. Protein kinase C, but not tyrosine kinases or Ras, plays a critical role in angiotensin II-induced activation of Raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytes: Y. Zou et al.; J. Biol. Chem. 271, 33592 (1996)
  5. Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells: A. Di Paolo, et al.; Br. J. Cancer 82, 905 (2000)
  6. Manumycin A and its analogues are irreversible inhibitors of neutral sphingomyelinase: C. Arenz, et al.; ChemBioChem 2, 141 (2001)
  7. Enhancement of manumycin A-induced apoptosis by methoxyamine in myeloid leukemia cells: M. She, et al.; Leukemia 19, 595 (2005)
  8. Binding of manumycin A inhibits IkappaB kinase beta activity: M. Bernier, et al.; J. Biol. Chem. 281, 2551 (2006)
  9. A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics: G. Porcu, et al.; Mol. Cancer 9:197 (2010)
  10. Targeting farnesyl-transferase as a novel therapeutcstrategy for mevalonate kinase defiency: In vitro and in vivo approaches: L. De Leo, et al.; Pharmacol. Res. 61, 506 (2010)
  11. Manumycin A corrects aberrant splicing of Clcn1 in myotonic dystrophy type 1 (DM1) mice: K. Oana, et al.; Sci. Rep. 3, 2142 (2013)
  12. Manumycin induces apoptosis in prostate cancer cells: J.G. Li, et al., Onco Targets Ther. 7, 771 (2014)
  13. The natural tumorcide Manumycin-A targets protein phosphatase 1α and reduces hydrogen peroxide to induce lymphoma apoptosis. G.B. Carey, et al.; Exp. Cell. Res. 332, 136 (2015)
  14. Manumycin A from a new streptomyces strain induces endoplasmic reticulum stress-mediated cell death through specificity protein 1 signaling in human oral squamous cell carcinoma: C.J. Jae, et al.; Int. J. Oncol. 47, 1954 (2015)
  15. Manumycin A downregulates release of proinflammatory cytokines from TNF alpha stimulated human monocytes: E. Cecrdlova, et al.; Immunol. Lett. 169, 8 (2016)
  16. Manumycin A Is a Potent Inhibitor of Mammalian Thioredoxin Reductase-1 (TrxR-1): A. Tuladhar & K.S. Rein; ACS Med. Chem. Lett. 9, 318 (2018)


目次に戻る

カートに商品を
追加しました。

お問い合わせ先

（テクニカルサポート 試薬担当）

reagent@funakoshi.co.jp

製品情報は掲載時点のものですが、価格表内の価格については随時最新のものに更新されます。お問い合わせいただくタイミングにより製品情報・価格などは変更されている場合があります。
表示価格に、消費税等は含まれていません。一部価格が予告なく変更される場合がありますので、あらかじめご了承下さい。