Bafilomycin C1 (CAS: 88979-61-7)

• 2025/11/04

  試薬 特別価格

  [KOM]低分子化合物 20％OFF・InVivoKines/B-Xpander 30％OFFキャンペーン[～2026/02/27] NEW

  期間：2025/11/04 ～2026/02/27

  Adipogen Life Sciences（KOM）

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• 製品情報

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製品情報

商品コード	BVT-0068
品名	Bafilomycin C1
分子式	C39H60O12
分子量	720.9
CAS	88979-61-7
構造式
純度	≥98% (HPLC)
形状	Yellow powder.
別名	L-681,110A1; 2-Demethyl-2-methoxy-24-methyl-hygrolidin
特長	Antibiotic. Specific vacuolar-type H+-ATPase inhibitor. Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases. Antibacterial, insecticidal and anthelmintic. Antifungal activity, especially against C. albicans. Potential anti-osteoporotic agent in treating bone lytic diseases. Neuroprotection inducer. Cytotoxic activity against SMMC7721 HCC cells. Potential candidate for hepatic carcinoma chemotherapy.
文献	Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. (Tokyo) 37, 110 (1984) Purification of vacuolar ATPase with bafilomycin C1 affinity chromatography: T.J. Rautiala, et al.; BBRC 194, 50 (1993) Bafilolides, potent inhibitors of the motility and development of the free-living stages of parasitic nematodes: E. Lacey, et al.; Int. J. Parasitol. 25, 349 (1995) Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection: J.J. Shacka, et al.; Autophagy 2, 228 (2006) (Review) Structure and function of V-ATPases in osteoclasts: potential therapeutic targets for the treatment of osteolysis: J. Xu, et al.; Histol. Histopathol. 222, 443 (2007) Low-dose Bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction: V. Pivtoraiko, et. al.; J. Neurochem. 114, 1193 (2010) Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption-implications for osteoclast quality: A. Neutzsky-Wulff, et. al.; BMC Musculoskel. Disord. 11, 1471 (2010) Bafilomycins and Odoriferous Sesquiterpenoids from Streptomyces albolongus Isolated from Elephas maximus Feces: N. Ding, et al.; J. Nat. Prod., 79, 799 (2016) Bafilomycin C1 exert antifungal effect through disturbing sterol biosynthesis in Candida albicans: H. Su, et al.; J. Antibiot. 71, 467 (2018) Bafilomycin C1 induces G0/G1 cell-cycle arrest and mitochondrial-mediated apoptosis in human hepatocellular cancer SMMC7721 cells: X. Gao, et al.; J. Antibiot. 71, 808 (2018)

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