Fulvic Acid (CAS: 479-66-3)

C₁₄H₁₂O₈

• Free radical scavenger and antioxidant [1].
• Potential compound to neutralize radioactive and toxic wastes and "heal" soils. Chelates and binds scores of minerals into a bioavailable form used by cells [1].
• Shown to incorporate into bone and cartilage of rats [2].
• Antibacterial [3].
• Antifungal [3].
• β-Hexosaminidase release inhibitor [4].
• Anti-inflammatory [5].
• Tau fibrils aggregation inhibitor (Alzheimers Disease) [6].
• Antiseptic [7].
• Interrupts the dimer formation of Aβ(17-42) peptides [8].

1. Studies in the biochemistry of micro-organisms: Fulvic acid, a new crystalline yellow pigment, a metabolic product of P. griseo-fulvum Dierckx, P. flexuosum Dale and P. Brefeldianum Dodge: A.E. Oxford, et al.; Biochem. J. 29, 1102 (1935)
2. The evidence for the incorporation of fulvic acid into the bone and cartilage of rats: C. Wang, et al. Sci. Total Environ. 19, 197 (1996)
3. An in vitro investigation of the antimicrobial activity of oxifulvic acid: C.E. J. van Rensburg, et al.; J. Antimicrob. Chemother. 46, 853 (2000)
4. Properties of fulvic acid extracted from excess sludge and its inhibiting effect on beta-hexosaminidase release: H. Motojima, et al.; Biosci. Biotechnol. Biochem. 73, 2210 (2009)
5. Carbohydrate-derived fulvic acid (CHD-FA) inhibits carrageenan-induced inflammation and enhances wound healing: efficacy and toxicity study in rats: R. Sabi, et al.; Drug Dev. Res. 73, 18 (2011)
6. Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer's disease: A. Cornejo, et al.; J. Alzheim. Dis. 27, 143 (2011)
7. Carbohydrate Derived Fulvic Acid: An in vitro Investigation of a Novel Membrane Active Antiseptic Agent Against Candida albicans Biofilms: L. Sherry, et al.; Front. Microbiol. 3, 116 (2012)
8. The effect of fulvic acid on pre- and postaggregation state of Aβ(17-42): Molecular dynamics simulation studies: S. Verma, et al.; Biochim. Biophys. Acta 1834, 24 (2013)