Bikaverin (CAS: 33390-21-5)

C₂₀H₁₄O₈

• Antibiotic [1].
• Antiprotozoal [1].
• Antifungal [2].
• Anticancer [3-7].
• ATP synthesis inhibitior [3, 4].
• Haemolytic agent [5].
• Antioomycete [8].
• Spermidine-induced autoactivation inhibitor [9].
• Plasma hyaluronan-binding protein (PHBP) inhibitor (active form) [9].
• Review [10].

1. Bikaverin, an antibiotic from ibberella fujikoi, effective against Leishmania brasiliensis: J. Balan, et al.; Folia Microbiol. 15, 479 (1970)
2. Isolation and characterization of a fungal vacuolation factor (bikaverin): J.W. Cornforth, et al.; J. Chem. Soc. Perkin 16, 2786 (1971)
3. New potential cytotoxic and antitumor substances I. In vitro effect of bikaverin and its derivatives on cells of certain tumors: J. Fuska, et al.; Neoplasma  22, 335 (1975)
4. Effects of bikaverin on purine nucleotide synthesis and catabolism in Ehrlich ascites tumor cells in vitro: J.F. Henderson, et al.; Biochem. Pharmacol. 26, 1973 (1977)
5. Inhibition of mitochondrial functions by the antibiotics, bikaverin and duclauxine: L. Kovac, et al.; J. Antibiot. (Tokyo) 31, 616 (1978)
6. Effects of selected secondary metabolites of Fusarium moniliforme on unscheduled synthesis of DNA by rat primary hepatocytes: W.P. Norred, et al.; Food Chem. Toxicol. 30, 233 (1992)
7. Search for cell motility and angiogenesis inhibitors with potential anticancer activity: beauvericin and other constituents of two endophytic strains of Fusarium oxysporum: J. Zhan, et al.; J. Nat. Prod. 70, 227 (2007)
8. Bikaverin and fusaric acid from Fusarium oxysporum show antioomycete activity against Phytophthora infestans: S.W. Son, et al.; J. Appl. Microbiol. 104, 692 (2008)
9. Purpurin as a specific inhibitor of spermidine-induced autoactivation of the protease plasma hyaluronan-binding protein: N. Nishimura, et al.; Biol. Pharm. Bull. 33, 1430 (2010)
10. Bikaverin production and applications: M.C. Limon, et al.; Appl. Microbiol. Biotechnol. 87, 21 (2010) (Review)