Terpendole E (CAS: 167427-23-8)

C₂₈H₃₉NO₃

• Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor [1, 2].
• Mitotic kinesin Eg5 (Mitotic Kinesin Spindle Protein; KSP) inhibitor [3-7].
• Specific M phase inhibitor [4]. 

1. Microbial metabolites affecting lipid biosynthesis: S. Omura & H. Tomoda; Pure Appl. Chem. 66, 2267 (1994)
2. Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. I. Production, isolation and biological properties: X.H. Huang, et al.; J. Antibiot. (Tokyo) 48, 1 (1995)
3. A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5: J. Nakazawa, et al.; Chem. Biol. 10, 131 (2003)
4. Development and application of bioprobes for Mammalian cell cycle analyses: H. Osada; Curr. Med. Chem. 10, 727 (2003) (Review)
5. Docking studies on kinesin spindle protein inhibitors: an important cooperative 'minor binding pocket' which increases the binding affinity significantly: C. Jiang, et al.; J. Mol. Model  13, 987 (2007)
6. A novel approach to indoloditerpenes by Nazarov photocyclization: synthesis and biological investigations of terpendole E analogues: F. Churruca, et al.; Org. Lett. 12, 2096 (2010)
7. Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds: S. Oishi, et al.; J. Med. Chem. 53, 5054 (2010)