抗FPRL1/FPR2抗体 | Anti-FPRL1/FPR2 Antibody

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	Western Blot: FPRL1 Antibody [NLS1878] - WB analysis of FPRL1 in HL-60 cell lysate.
	Immunocytochemistry/Immunofluorescence: FPRL1 Antibody [NLS1878] - FPRL1 antibody was tested in Raw264.7 cells with Dylight 488 (green). Nuclei were counterstained with DAPI (blue).
	Immunohistochemistry: FPRL1 Antibody [NLS1878] - IHC analysis of FPRL1 in human kidney cancer using DAB with hematoxylin counterstain.

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Background

FPRL1 (formyl peptide receptor-like-1 or N-formyl peptide receptor 2) is a multi-pass membrane protein receptor belonging to the GPCR1 family and is expressed abundantly in lungs and neutrophils. Among human FPRs and its variants (FPRL1/FPR-like 1 and FPRL2/FPR-like 2), FPRL1 is less efficiently activated by N-fMLP (N-formylmethionylleucylphenylalanine) than FPR and certain agonists which bind FPRL1 with high affinity includes lipoxin A4 eicosanoid, annexin 1, uPAR, the V3 region of the HIV-1 envelope glycoprotein gp120, the acute-phase protein SAA, the 42-amino-acid form of beta-amyloid, human prion peptide, and cathelicidin LL-37. FPRL1 binding to its agonists triggers the activation of intracellular signaling molecules including calcium, PKC isoforms, phospholipases A2 and D, and MAPKs/p38MAPK. FPRL1 activation may result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as leukotriene B4. Expression of FPR1, FPRL1, and FPRL2 has recently been documented to enhance invasive potential of melanoma cells. Moreover, FPRL1 interacts with amyloid beta peptides is implicated in phagocyte attraction to sites of amyloid plaques in Alzheimer's disease.

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