抗Tight Junction Protein 1抗体 | Anti-Tight Junction Protein 1 Antibody
掲載日情報:2018/07/09 現在Webページ番号:50351
世界最大級の抗体製品数を取り扱うNovus Biologicals社のTight Junction Protein 1に対する抗体(anti-Tight Junction Protein 1 | antibody Tight Junction Protein 1)です。Novus Biologicals社の抗体は数多くの学術論文で使用実績があります。
※本製品は研究用です。研究用以外には使用できません。
追加しました。
価格
[在庫・価格 :2024年05月03日 00時01分現在]
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Anti-ZO-1 tight junction protein, Guinea Pig-Poly |
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Anti-Tight Junction Protein 1, Guinea Pig-Poly |
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[在庫・価格 :2024年05月03日 00時01分現在]
Anti-ZO-1 tight junction protein, Guinea Pig-Poly
文献数: 2
- 商品コード:NBP1-49669
- メーカー:NOV
- 包装:0.1mg
- 価格:¥132,000
- 在庫:無(未発注)
- 納期:3~4週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 |
Keywords:DKFZp686M05161|MGC133289|Tight junction protein 1|tight junction protein 1 (zona occludens 1)|tight junction protein ZO-1|TJP1|ZO1|ZO-1|zona occludens 1|Zona occludens protein 1|zonula occludens 1 protein|Zonula occludens protein 1 Genbank No: 7082 Protein Accession No: Q07157 |
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別包装品 | 別包装品あり | ||||||
法規制等 | |||||||
保存条件 | 4℃,凍結禁止 | 法規備考 | |||||
抗原種 | 免疫動物 | Guinea Pig | |||||
交差性 | Canine/Human/Mouse | 適用 | IC,IF,IHC,Western Blot | ||||
標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
吸収処理 | クラス | IgG | |||||
クロナリティ | Polyclonal | フォーマット | |||||
掲載カタログ |
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製品記事 | |||||||
関連記事 |
Anti-Tight Junction Protein 1, Guinea Pig-Poly
文献数: 2
- 商品コード:NBP1-49669
- メーカー:NOV
- 包装:0.05mg
- 価格:¥72,000
- 在庫:無(未発注)
- 納期:3~4週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 |
Keywords:DKFZp686M05161|MGC133289|Tight junction protein 1|tight junction protein 1 (zona occludens 1)|tight junction protein ZO-1|TJP1|ZO1|ZO-1|zona occludens 1|Zona occludens protein 1|zonula occludens 1 protein|Zonula occludens protein 1 Genbank No: 7082 Protein Accession No: Q07157 |
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別包装品 | 別包装品あり | ||||||
法規制等 | |||||||
保存条件 | 法規備考 | ||||||
抗原種 | 免疫動物 | Guinea Pig | |||||
交差性 | Canine/Human/Mouse | 適用 | IC,IF,IHC,Western Blot | ||||
標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
吸収処理 | クラス | IgG | |||||
クロナリティ | Polyclonal | フォーマット | |||||
掲載カタログ |
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製品記事 | |||||||
関連記事 |
追加しました。
Background
The polyclonal antibody recognizes human zona occludens 1 (ZO-1), an ~220 kDa tight junction protein belonging to the membrane-associated guanlyate kinase (MAGUK) family. Members of this family are involved in epithelial and endothelial intercellular junctions. They each contain at least one PSD95/Dlg/ZO-1 (PDZ) domain, a Src homology 3 (SH3) domain, and an enzymatically inactive guanylate kinase domain. PDZ domains are 90-amino acid protein-protein binding domains that recognize at least a 3-residue peptide motif in the COOH termini of their binding partners. PDZ domain-containing proteins, like ZO-1, typically act as scaffolding proteins that organize membrane receptors and cytosolic proteins into multimeric signaling complexes often at the sites of cell-cell contact. The effectiveness and stability of the epithelial barrier depends on a complex of proteins composing different intercellular junctions, which include tight junctions, adherens junctions, and desmosomes. ZO-1 is a peripheral membrane protein bound on the cytoplasmic surface of junctional contacts and is expressed in all tight junctions regardless of their properties. ZO-1 immunoprecipitates with its family member ZO-2. ZO-1 was shown to undergo tyrosine phosphorylation during tight junction formation and remodeling. Two different isoforms of ZO-1, alpha-minus and alpha-plus, have been described, which result from alternative splicing of an mRNA encoded by a single gene. The ZO-1 alpha-plus contains an 80 amino acids motif called alpha which is not present in ZO-1 alpha-minus. The alpha-containing isoform is found in most epithelial cell junctions. The short isoform (ZO-1 alpha-minus) is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules. This difference in distribution provides molecular distinction among tight junctions.追加しました。
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