抗Integrin alpha 2b/CD41 (MWReg30)抗体 | Anti-Integrin alpha 2b/CD41 (MWReg30) Antibody

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Image

	Flow Cytometry: Integrin alpha 2b/CD41 Antibody (MWReg30) [NBP1-43415] - Analysis using the Biotin conjugate of NBP1-43415. Staining of mouse platelets with Anti-Mouse/Rat CD61 (Integrin beta 3) FITC and 0.06 ug of Rat IgG1 K Isotype Control Biotin (left) or 0.06 ug of Anti-Mouse CD41 Biotin (right) followed by Streptavidin PE.
	Flow Cytometry: Integrin alpha 2b/CD41 Antibody (MWReg30) [NBP1-43415] - Staining of mouse platelets with 0.125 ug of Rat IgG1 Isotype Control Purified (left) or 0.125 ug of Anti-Mouse CD41 Purified (right) followed by Anti-Rat IgG PE.

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Background

The MWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alphaIIb). While initially thought to be expressed exclusively on the surface of platelets and megakaryocytes, it has been demonstrated that CD41 is also expressed on hematopoietic progenitors in the embryo, fetus and adult. CD41 associates with CD61 (gpIIIa, integrin betaIII) to form a receptor which plays a major role in platelet function, including binding of several adhesion molecules such as fibrinogen, fibronectin and vitronectin. Recently, the SLAM-family markers, CD48 and CD150 have been used to reliably identify hematopoietic stem cells (HSC). Specifically, it was found that CD150+CD48- bone marrow cells were highly efficient in their ability to confer long-term multi-lineage reconstitution in irradiated mice. Furthermore, the efficiency of reconstitution was enhanced when HSCs were further enriched through the exclusion of CD41+ cells. Thus, the use of CD150+CD48-CD41- as an expression profile efficiently identifies hematopoietic stem cells.

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