抗Aflatoxin B1 (6A10)抗体 | Anti-Aflatoxin B1 (6A10) Antibody

• 価格
• Image
• Background

価格

目次に戻る

Image

Immunohistochemistry: Aflatoxin B1 Antibody (6A10) [NB600-443] - Immuno staining of positive (A) and negative (B) tumor tissues for AFB, -DNA adducts. Photos courtesy of Dr. Regina Santella.

目次に戻る

Background

Aflatoxins (AF) are a group of harmful fungal toxins commonly found as grains/groundnuts contaminants and the most abundant congeners of AF, aflatoxin B1 (AFB1) is the most toxic among AFs which is produced by Aspergillus flavus, A. parasiticus etc. Humans and domestic animals can be exposed to aflatoxins by foods and approximately 25% of the world's food supply is annually contaminated with mycotoxins indicating the widespread prevalence of this public health problem. AFB1, a potent hepatotoxin/hepatocarcinogen, undergoes metabolism catalyzed by mixed function oxygenases of hepatic cytochrome P-450 enzyme system to produce a highly reactive intermediate, aflatoxin B1-8,9 epoxide that binds to necleophilic sites in hepatocyte DNA to form a number of adducts. The reactive aflatoxin B1-8,9 epoxide attracts guanine residues in double stranded DNA and the adducts formation leads to initiation of hepatocarcinogenesis. ROS generated during aflatoxins metablosm are considered to be main culprit for hepatotoxicity. The AFB1-8,9-epoxide can further be converted to AFB1-8,9-diol that specifically binds to lysine in albumin and forms AFB1-lysine adducts (AFB-Lys), which has been validated as a biomarker of human aflatoxins exposure.

目次に戻る