抗CD11b (M1/70.15)抗体 | Anti-CD11b (M1/70.15) Antibody

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	Immunohistochemistry: CD11b Antibody (M1/70.15) [NB600-1327] - Analysis of frozen lymph node section followed by staining with HRP secondary antibody.
	Immunocytochemistry/Immunofluorescence: CD11b Antibody (M1/70.15) [NB600-1327] - Characterization of microglia cultures by multiple staining with anti CD11b (panels a. & c.) and anti GFAP (panels b & d). Nuclei appear blue due to DAPI counter staining.
	Flow Cytometry: CD11b Antibody (M1/70.15) [NB600-1327] - Analysis using the Alexa Fluor (R) 488 conjugate of NB600-1327. Staining of mouse peritoneal macrophages using Alexa Fluor 488 conjugated CD11b antibody (clone M1/70.15).
	Flow Cytometry: CD11b Antibody (M1/70.15) [NB600-1327] - Staining of mouse peritoneal macrophages with Rat anti Mouse CD11b:RPE
	Flow Cytometry: CD11b Antibody (M1/70.15) [NB600-1327] - Staining of mouse peritoneal macrophages with Rat anti Mouse CD11b
	Flow Cytometry: CD11b Antibody (M1/70.15) [NB600-1327] - Staining of total mouse peritoneal exudate cells demonstrating labelling of macrophages with Rat anti Mouse CD11b:RPE
	Immunocytochemistry/Immunofluorescence: CD11b Antibody (M1/70.15) [NB600-1327] - ICC/IF analysis of RAW264.7 cells using CD11b antibody (clone M1/70.15) with Dylight 488 conjugated secondary (green). Nuclei and tubulin were stained with DAPI (blue) and Dylight 550 (red).
	Flow Cytometry: CD11b Antibody (M1/70.15) [NB600-1327] - Staining of mouse peritoneal macrophages cells.
	Flow Cytometry: CD11b Antibody (M1/70.15) [NB600-1327] - Staining of mouse peritoneal macrophages with Rat anti Mouse CD11b: RPE - Alexa Fluor 750
	Flow Cytometry: CD11b Antibody (M1/70.15) [NB600-1327] - Staining of mouse peritoneal macrophages with Rat anti Mouse CD11b

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Background

Integrins are a family of heterodimeric transmembrane receptor proteins and they contains alpha as well as beta subunits. The Integrin alpha M subunit, also known as MAC-1 alpha subunit or CD11b, combines with the Integrin beta 2 subunit/CD18 to form the non-covalent heterodimer Integrin alpha M/beta 2, also known as MAC-1 and complement receptor type 3 /CR3. The Mac-1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, blood monocytes. CD11b is expressed on 8% spleen cells, 44% bone marrow cells and less than 1% of thymocytes and is commonly used as a microglial marker in nervous tissue. CD11b is involved in adhesive interactions of monocytes, macrophages and granulocytes, and in mediating the uptake of complement coated particles. It has been shown to act as a receptor of iC3b, fibrinogen, factor-X, ICAM1, extracellular dsRNA, PAMP/DAMPs, aggregated beta-Amyloid and HMGB1. Variations at the ITGAM gene, which encodes for the CD11b chain of the Mac-1 integrin, is one of the main genetic risk factors involved in systemic lupus erythematosus /SLE disorder.

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