抗Calnexin (AF18)抗体 | Anti-Calnexin (AF18) Antibody

• 価格
• Image
• Background

価格

目次に戻る

Image

	Western Blot: Calnexin Antibody (AF18) [NB300-518] - Analysis of 25 ug of HepG2 lysate.
	Immunocytochemistry/Immunofluorescence: Calnexin Antibody (AF18) [NB300-518] - Staining of calnexin (red) in U87 cells.
	Immunohistochemistry-Paraffin: Calnexin Antibody (AF18) [NB300-518] - Both normal and cancer biopsies of deparaffinized Human hepatocarcinoma tissues.
	Immunocytochemistry/Immunofluorescence: Calnexin Antibody (AF18) [NB300-518] - Transfected COS7 cells were blocked in 1% BSA, 5% normal goat serum, and 0.1% Triton X-100 in 1X PBS, and then stained (1:500), followed by a fluorophore-conjugated goat anti-mouse IgG secondary antibody (red).
	Immunocytochemistry/Immunofluorescence: Calnexin Antibody (AF18) [NB300-518] - Staining of Calnexin in A549 Cells.
	Immunocytochemistry/Immunofluorescence: Calnexin Antibody (AF18) [NB300-518] - Staining of HMVEC Cells.
	Immunohistochemistry-Paraffin: Calnexin Antibody (AF18) [NB300-518] - Normal deparaffinized Human kidney tissue tissues.

目次に戻る

Background

Calnexin, also referred to as IP90, p88 and p90, is an ~90 kDa integral membrane protein of the endoplasmic reticulum (ER). Many resident ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multisubunit proteins. Studies indicate that calnexin associates with the major histocompatability complex (MHC) class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes. It has been shown that calnexin is a chaperone that retains incompletely or improperly folded proteins in the ER. The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble ER resident proteins such as GRP78 and GRP94 and protein disulfide isomerase. (See catalog #

目次に戻る