抗Collagen IV alpha 1抗体 | Anti-Collagen IV alpha 1 Antibody

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• Background

価格

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Image

	Immunohistochemistry-Paraffin: Collagen IV alpha 1 Antibody [NB120-6586] - Analysis using the Biotin conjugate of NB120-6586. Staining of Collagen IV alpha 1 (red) and Insulin (green) in mouse pancreas. Image from verified customer review.
	Immunohistochemistry-Paraffin: Collagen IV alpha 1 Antibody [NB120-6586] - Analysis of Collagen IV in various paraffin embedded human tissues. Image courtesy of product review submitted by Daniel Pirici.
	Immunohistochemistry-Paraffin: Collagen IV alpha 1 Antibody [NB120-6586] - Used at a dilution of 1:400, 45 min RT showed strong staining in FFPE sections of human kidney (Left) with strong red staining observed in glomeruli and liver (Right) with strong staining in sinusoids. Staining for both tissues was consistent with a basement membrane distribution. Slides were steamed in 0.01 M sodium citrate buffer, pH 6.0 at 99-100C - 20 minutes for antigen retrieval.
	Immunohistochemistry-Paraffin: Collagen IV alpha 1 Antibody [NB120-6586] - Analysis of Collagen IV alpha 1 in paraffin embedded mouse cervix tissue using anti-Collagen IV alpha 1 antibody. Image from verified customer review.

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Background

This antibody is well suited to detect extracellular matrix proteins in normal as well as disease state tissues. Disruption of tissue organization is the hallmark of neoplasia. Malignant lesions can be distinguished from benign by examining the breakdown of basement membranes and loss of 3-dimensional architecture. Malignant cells are presumed to use matrix metalloproteases to degrade barriers created by the extracellular matrix which then allows metastasis to occur. Collagenases, stomelysins and gelatinases can collectively degrade all of the various components of the extracellular matrix, including fibrillar and non-fibrillar collagens and basement membrane glycoproteins.

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