抗Glutathione S-Transferase pi 1/GSTP1 (3F2C2)抗体 | Anti-Glutathione S-Transferase pi 1/GSTP1 (3F2C2) Antibody

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	Western Blot: Glutathione S-Transferase pi 1/GSTP1 Antibody (3F2C2) [NB110-60512] - Analysis using GSTP1 mouse mAb against HEK293T cells transfected with the pCMV6-ENTRY control (1) and pCMV6-ENTRY GSTP1 cDNA (2).
	Immunocytochemistry/Immunofluorescence: Glutathione S-Transferase pi 1/GSTP1 Antibody (3F2C2) [NB110-60512] - Analysis of HepG2 (left) and L-02 (right) cells using GSTP1 mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
	Immunohistochemistry-Paraffin: Glutathione S-Transferase pi 1/GSTP1 Antibody (3F2C2) [NB110-60512] - Analysis of human prostate tissues using GSTP1 mouse mAb with DAB staining.
	Flow Cytometry: Glutathione S-Transferase pi 1/GSTP1 Antibody (3F2C2) [NB110-60512] - Analysis of K562 cells using GSTP1 mouse mAb (green) and negative control (purple).
	Western Blot: Glutathione S-Transferase pi 1/GSTP1 Antibody (3F2C2) [NB110-60512] - Analysis using GSTP1 mouse mAb against PC3 cell lysate (1) and human cerebellum tissue lysate (2).
	Immunocytochemistry/Immunofluorescence: Glutathione S-Transferase pi 1/GSTP1 Antibody (3F2C2) [NB110-60512] - Analysis of PC-3 cells using GSTP1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
	ELISA: Glutathione S-Transferase pi 1/GSTP1 Antibody (3F2C2) [NB110-60512] - Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng).

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Background

GSTP1 (glutathione-S-transferase, pi 1), also called GST3/DFN7, which is located on chromosome 11q13, is a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. GSTP1 act like a tumor suppressor gene, which when inactivated leads to tumor growth, and the -class glutathione S-transferase is commonly inactivated by somatic CpGisland hypermethylation in cancers of the prostate, liver, and breast. Methylation of regulatory sequences at the GSTP1 gene locus is found in the vast majority (>90%) of prostate carcinomas and is associated with transcriptional down-regulation.

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