抗ASK1 (EP553Y)抗体 | Anti-ASK1 (EP553Y) Antibody

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Image

	Western Blot: ASK1 Antibody (EP553Y) [NB110-55482] - HeLa cell lysate using a 1:2000 dilution.
	Immunocytochemistry/Immunofluorescence: ASK1 Antibody (EP553Y) [NB110-55482] - HeLa cells.
	Immunohistochemistry: ASK1 Antibody (EP553Y) [NB110-55482] - Analysis of paraffin-embedded human lung carcinoma using ASK1 antibody
	Flow Cytometry: ASK1 Antibody (EP553Y) [NB110-55482] - ASK1 in human HL-1 cells.
	Flow Cytometry: ASK1 Antibody (EP553Y) [NB110-55482] - Overlay histogram showing HeLa cells stained with ASK1 antibody [EP553Y].

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Background

Apoptosis signal-regulating kinase-1 (ASK1, MEKK5, MAPKKK5) is a MAP3k type protein kinase belonging to mitogen-activated protein kinase kinase kinase (MAPKKK) family. As a regulator of JNK and p38 MAPK signaling pathways, ASK1/MEKK5 phosphorylates MMK4 to activate c-Jun N-terminal kinase (JNK) and phosphorylates MEK3 and MKK6 to activate p38. ASK1/MEKK5 is activated by oxidative stress, TNF via TRAF2, Fas via Daxx, calcium overload, and endoplasmic reticulum stress (1). ASK1/MEKK5 is inactivated by Trx, Grx, 14-3-3, and protein serine/threonine phosphatase 5 (2). While elevated level of ASK1/MEKK5 can induce apoptosis, a catalytically inactive ASK1/MEKK5 acts as an inhibitor in TNF-alpha induced apoptosis. Over-expression of ASK1/MEKK5 has also been implicated in cell differentiation, such as in keratinocyte differentiation through p38 pathway (3). ASK1/MEKK5 has been implicated as a therapeutic target for neurodegenerative disorder sand cardiac dysfunction (4).

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