抗ChemR23/CMKLR1抗体 | Anti-ChemR23/CMKLR1 Antibody

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	Western Blot: ChemR23/CMKLR1 Antibody [NB100-92428] - Analyzes of ChemR23 (R249) antibody in extracts from Jurkat cells
	Immunohistochemistry-Paraffin: ChemR23/CMKLR1 Antibody [NB100-92428] - Analyzes of ChemR23 (R249) pAb in paraffin-embedded human stomach carcinoma tissue at 1:50.showing cytoplasmic and nucleus staining. Negative control (the right)Using PBS instead of primary antibody.
	Western Blot: CMKLR1 Antibody [NB100-92428] - Lane1:Jurkat whole cell lysate. Lane2:Mouse liver tissue lysate. Lane3:Rat liver tissue lysate.
	Immunohistochemistry-Paraffin: ChemR23/CMKLR1 Antibody [NB100-92428] - Analyzes of ChemR23 (R249) pAb in paraffin-embedded human kidney carcinoma tissue at 1:50.showing cytoplasmic and nucleus staining. Negative control (the right) Using PBS instead of primary antibody.

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Background

The C-X3-C chemokine family is characterized by two cysteines separated by three amino acid residues. Fractalkine is a member of this chemokine family that binds CX3CR1, previously named V28, and chemokine beta receptor-like 1 (CMKBRL1) with high affinity, to induce either leukocyte adhesion and migration or chemotactic functions. CX3CR1 functions with CD4 as a co-receptor for the HIV-1 virus envelope protein, and patients homozygous for a variant haplotype of CX3CR1 progress to AIDS more rapidly than those with other haplotypes. Chemokine receptor-like 1 (also designated G protein-coupled receptor DEZ or ChemR23) belongs to the G protein-coupled receptor 1 family. It is an integral membrane protein functioning as a receptor, possibly a chemotactic peptide receptor. It also acts as a co-receptor for various SIV strains and for a primary HIV-1 strain. ChemR23 is highly expressed in developing osseous and cartilaginous tissue, brain, kidney, gastrointestinal tissues and myeloid tissue, as well as in adult parathyroid glands.

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