抗TGF-beta 1抗体 | Anti-TGF-beta 1 Antibody

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価格

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Image

	Western Blot: TGF-beta 1 Antibody [NB100-91995] - Western blot (WB) analysis of TGF beta-1 (Y369) pAb in extracts from HepG2 cells.
	Immunohistochemistry-Paraffin: TGF-beta 1 Antibody [NB100-91995] - Paraffin-embedded human breast carcinoma tissue.
	Western Blot: TGF-beta 1 Antibody [NB100-91995] - Lane1:Hela cell lysate. Lane2:SP2/0 cell lysate. Lane3:H9C2 cell lysate. Lane4:MCF-7 cell lysate.

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Background

Transforming growth factor betas (TGFbetas) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGFalpha. It is now realized that TGFbetas mediate many cell-cell interactions that occur during embryonic development. Three TGFbetas have been identified in mammals. TGFbeta1, TGFbeta2 and TGFbeta3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFbeta requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFbeta3 protein has approximately 80% identity to the mature region of both TGFbeta1 and TGFbeta2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity.

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