抗B220/CD45R (RA3-6B2)抗体 | Anti-B220/CD45R (RA3-6B2) Antibody

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	Flow Cytometry: B220/CD45R Antibody (RA3-6B2) [NB100-77420] - Analysis of Biotin conjugate of NB100-77420. Staining of BALB/c splenocytes with 0.06 ug of Rat IgG2a kappa Isotype Control Biotin (open histogram) or 0.06 ug of Anti-Human/Mouse CD45R (B220) Biotin (filled histogram) followed by Streptavidin PE. Total v
	Flow Cytometry: B220/CD45R Antibody (RA3-6B2) [NB100-77420] - C57BL/6 mouse splenocytes stained with purified RA3-6B2, followed by anti-rat IgG FITC
	Flow (Cell Surface): B220/CD45R Antibody (RA3-6B2) [NB100-77420] - Analysis using the Alexa Fluor (R) 488 conjugate of NB100-77420. Staining of CD45R on 10^6 BALB/c mouse splenocytes using 0.25 ug of this antibody. Green histogram represents isotype control; red represents CD45R antibody. Cell surface flow kit was used for this test (cells were not fixed for testing).
	Flow (Cell Surface): B220/CD45R Antibody (RA3-6B2) [NB100-77420] - Analysis using the Alexa Fluor (R) 647 conjugate of NB100-77420. Staining of CD45R on 10^6 BALB/c mouse splenocytes using 0.25 ug of this antibody. Green histogram represents isotype control; red represents CD45R antibody. Cell surface flow kit was used f
	Flow Cytometry: B220/CD45R Antibody (RA3-6B2) [NB100-77420] - Analysis using the Cy5 conjugate of NB100-77420. Multiple staining of BALB/c splenocytes.
	Flow Cytometry: B220/CD45R Antibody (RA3-6B2) [NB100-77420] - Analysis of Alexa Fluor (R) 488 conjugate of NB100-77420. Cell surface CD45R on 10^6 BALB/c mouse splenocytes using 0.25 ug of this antibody. Green histogram represents isotype control; red represents CD45R antibody. Cell surface flow kit was used for thi

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Background

CD45R is an isoform of CD45, also known as B220. It is a member of the protein tyrosine phosphatase (PTP) family with a molecular weight approximately 180-240 kD. CD45R is expressed on B cells (at all developmental stages from pro-B cells through mature B cells), activated B cells, subsets of T and NK cells. CD45R (B220) is also expressed on a subset of abnormal T cells involved in the pathogenesis of systemic autoimmunity in MRL-Faslpr and MRL-Fasgld mice. It plays a critical role in TCR and BCR signaling. The primary ligands for CD45 are galectin-1, CD2, CD3, and CD4. CD45R is commonly used as a pan-B cell marker; however, CD19 may be more appropriate for B cell specificity.

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