抗Pericentrin抗体 | Anti-Pericentrin Antibody

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	Biological Strategies Validation. Western Blot: Pericentrin Antibody [NB100-61071] - Detection of Human Pericentrin/Kendrin by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa and 293T cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-Pericentrin/Kendrin antibody NB100-61071 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
	Immunocytochemistry/Immunofluorescence: Pericentrin Antibody [NB100-61071] - Acetone-fixed asynchronous HeLa cells. Affinity purified rabbit anti- Pericentrin/Kendrin used at a dilution of 1:100.
	Immunocytochemistry/Immunofluorescence: Pericentrin Antibody [NB100-61071] - NBF-fixed asynchronous HeLa cells. Affinity purified rabbit anti- Pericentrin/Kendrin used at a dilution of 1:100.
	Immunocytochemistry/Immunofluorescence: Pericentrin Antibody [NB100-61071] - NBF-fixed asynchronous HeLa cells. Affinity purified rabbit anti-Pericentrin/Kendrin used at a dilution of 1:500.
	Immunocytochemistry/Immunofluorescence: Pericentrin Antibody [NB100-61071] - NBF-fixed asynchronous HeLa cells. Affinity purified rabbit anti-Pericentrin/Kendrin used at a dilution of 1:500.

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Background

Pericentrin (PCNT) is a large centrosomal protein that binds calmodulin and mediates assembly of the mitotic spindle apparatus. Depletion of PCNT has been shown to cause apoptosis and activation of the G2/M checkpoint. Recently, mutations in the pericentrin gene have been identified as the cause of primordial dwarfism type II (MOPDII) and Seckel syndrome. Additionally, in cells of Seckel syndrome patients, PCNT has been found to be important to the DNA damage response and ATR-dependent checkpoint signaling.

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