抗TLR2 (1030A5.138)抗体 | Anti-TLR2 (1030A5.138) Antibody

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Image

	Western Blot: TLR2 Antibody (1030A5.138) [NB100-56728] - Analysis of TLR2 in 30 ugs of Ramos whole cell lysate using TLR2 antibody at 1:500.
	Immunohistochemistry-Paraffin: TLR2 Antibody (1030A5.138) [NB100-56728] - Analysis of human spleen tissue using 40 ul of TLR2 antibody.
	Flow Cytometry: TLR2 Antibody (1030A5.138) [NB100-56728] - Surface flow analysis of TLR2 on 10^6 human monocytes using 2.5 ul of TLR2 antibody. The shaded histogram represents cells with no antibody present; green represents isotype control this antibody; red represents TLR2 antibody. Goat anti mouse IgG1 PE secondary was used.
	Immunohistochemistry-Paraffin: TLR2 Antibody (1030A5.138) [NB100-56728] - Analysis of TLR2 in paraffin-embedded human spleen tissue using NB100-56728 at 1:100 (left) and isotype control (right).
	Flow Cytometry: TLR2 Antibody (1030A5.138) [NB100-56728] - Analysis of TLR2 in 10^6 ThP1 cells using 5 ul of NB100-56728. The shaded histogram represents ThP1 cells with no antibody present; green represents isotype control); red represents NB100-56728 antibody.

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Background

The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). TLR2 is differentially expressed in human cells. TLR2 is expressed in tonsils, lymph nodes, and appendices, activated B-cells in germinal centers. CD14+ monocytes expressed the highest level of TLR2 followed by CD15+ granulocytes, and CD19+ B-cells, CD3+ T-cells, and CD56+ NK cells did not express TLR2. The expression of TLR2 on different cell types are regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes (4).

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