抗TRAF-5抗体 | Anti-TRAF-5 Antibody

• 価格
• Image
• Background

価格

目次に戻る

Image

	Western Blot: TRAF-5 Antibody [NB100-56178] - TRAF5 in normal human tissues using this antibody. TRAF5 is observed at ~64 kDa. Additional bands of lower molecular weight were seen in some cases, and may represent TRAF5 degradation fragments.
	Immunohistochemistry-Paraffin: TRAF-5 Antibody [NB100-56178] - Formalin-fixed, paraffin-embedded mouse tissue stained for TRAF5 expression using NB100-56178 at 1:2000. Hematoxylin-eosin counterstain. A, thymus. B, bone marrow.
	Immunohistochemistry: TRAF-5 Antibody [NB100-56178] - Formalin-fixed, paraffin-embedded mouse spleen stained for TRAF5 expression using NB100-56178 at 1:2000. Hematoxylin-eosin counterstain. A1 is a higher magnification of A.

目次に戻る

Background

The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis. NB100-56178 recognizes TRAF5. Mouse TRAF5 is a 558 amino acid protein.

目次に戻る