抗TRAF-1抗体 | Anti-TRAF-1 Antibody

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Image

	Western Blot: TRAF-1 Antibody [NB100-56170] - Analysis of TRAF-1 in normal human tissues using this antibody. TRAF-1 is observed at 50-50 kDa. Additional bands of lower molecular weight were seen in some cases, and may represent TRAF-1 degradation fragments.
	Immunohistochemistry-Paraffin: TRAF-1 Antibody [NB100-56170] - Formalin-fixed, paraffin-embedded human tissue sections stained for TRAF-1 expression using NB100-56170 at 1:2000. Hematoxylin-eosin counterstain. A, A1: Formalin-fixed, paraffin-embedded human lymphoma tissue section stained for TRAF-1 expression using NB100-56170 at 1:2000. Hematoxylin-eosin counterstain. A, Hodgkin'sDisease, the Reed-Sternberg cells are positive for TRAF-1 expression. B, lymph node, dendritic-like cells are positive for TRAF-1 expression. A1 and B1 are higher magnifications from A and B, respectively.
	Immunohistochemistry-Paraffin: TRAF-1 Antibody [NB100-56170] - Formalin-fixed, paraffin-embedded human lymphoma tissue section stained for TRAF-1 expression using NB100-56170 at 1:2000. Hematoxylin-eosin counterstain. A1 is a higher magnification of A.

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Background

The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis. This antibody recognizes TRAF1; human TRAF1 is a 416 amino acid protein.

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