抗gamma H2AX [p Ser139]抗体 | Anti-gamma H2AX [p Ser139] Antibody

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	Immunocytochemistry/Immunofluorescence: gamma H2AX [p Ser139] Antibody [NB100-2280] - Sample:~ Neocarzinostatin treated asynchronous HeLa cells fixed with NBF. Antibody: Affinity purified rabbit anti-gamma-H2AX used at a dilution of 1:100.~ Detection: Red fluorescent Anti-rabbit IgG-DyLight 594 conjugated used at a dilution of 1:100.
	Simple Western: gamma H2AX [p Ser139] Antibody [NB100-2280] - Simple Western lane view shows a specific band for gamma H2AX in 0.2 mg/ml of Jurkat lysate(s). This experiment was performed under reducing conditions using the 12 - 230 kDa separation system.
	Immunohistochemistry: gamma H2AX [p Ser139] Antibody [NB100-2280] - Sample: FFPE section of human stomach carcinoma. Antibody: Affinity purified rabbit anti-gamma H2AX~ used at a dilution of 1:250. Detection: DAB staining using Immunohistochemistry Accessory Kit.
	Simple Western: gamma H2AX [p Ser139] Antibody [NB100-2280] - Electropherogram image(s) of corresponding Simple Western lane view. Gamma H2AX antibody was used at 1:20 dilution on Jurkat lysate(s).

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Background

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. H2AX is an early responder to DNA damage, and its change to what is known as gamma-H2AX is important for the coordination of signaling and repair activities.

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