抗Musashi-1抗体 | Anti-Musashi-1 Antibody

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Image

	Western Blot: Musashi-1 Antibody [NB100-1759] - Detection of Musashi-1 protein in 10 ug of rat neural stem cell lysate (lane 1) and normal human brain lysate (lane 2) with Musashi-1 antibody NB100-1759 at a dilution of 1:500.
	Immunocytochemistry/Immunofluorescence: Musashi-1 Antibody [NB100-1759] - Staining with Musashi polyclonal antibody (1:100 dilution) shows Musashi (green) staining on neural rosettes (human). Nuclei are counterstained blue (DAPI). Cells were fixed with 4 percent PFA. No antigen retrieval was done.
	Immunocytochemistry/Immunofluorescence: Musashi-1 Antibody [NB100-1759] - Musashi-positive cells stained with Musashi antibody (1:150 dilution) in the ventricular zone of E14.5 mouse medulla. Image taken at 200x magnification. The sections were 4% PFA fixed, paraffin-embedded and cut at 5 microns.

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Background

Musashi1, a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells. Musashi-1 (Msi-1) has been shown to increase the accumulation of tau isoforms in intracellular inclusions in dementia. It may play a role in the pathogenesis of various neurodegenerative disorders. Musashi1 has also been detected in human tumor tissues such as gliomas and melanomas, suggesting its involvement in cancer development. Msi-1 also appears to play be an vital role in the development of several types of carcinoma such as human hepatoma, and may be a useful molecular marker for tumor detection.

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