抗beta-III Tubulin抗体 | Anti-beta-III Tubulin Antibody

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Image

	Immunocytochemistry/Immunofluorescence: beta-III Tubulin Antibody [NB100-1612] - Left panel: B-III Tubulin (Green); GFAP (Red); DAPI nuclear stain (Blue).
	Immunocytochemistry/Immunofluorescence: beta-III Tubulin Antibody [NB100-1612] - Dissociated cell culture of a neonatal mouse brain showing beta-III Tubulin (green staining) of neurons. These cultures were counter-stained with a rabbit anti-GFAP antibody (red staining) to identify astrocytes, and with DAPI (blue staining) to localize nuclei.

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Background

Beta-III tubulin is abundant in the central and peripheral nervous systems (CNS and PNS) where it is prominently expressed during fetal and postnatal development. As exemplified in cerebellar and sympathoadrenal neurogenesis, the distribution of beta III is neuron-associated, exhibiting distinct temporospatial gradients according to the regional neuroepithelia of origin. However, transient expression of this protein is also present in the subventricular zones of the CNS comprising putative neuronal- and/or glial precursor cells, as well as in Kulchitsky neuroendocrine cells of the fetal respiratory epithelium. This temporally restricted, potentially non-neuronal expression may have implications in the identification of presumptive neurons derived from embryonic stem cells. In adult tissues, the distribution of beta III tubulin is almost exclusively neuron-specific.

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