抗p97/VCP抗体 | Anti-p97/VCP Antibody

• 価格
• Image
• Background

価格

目次に戻る

Image

	Western Blot: p97/VCP Antibody [NB100-1558] - Whole cell lysate (15 ug) from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit antiVCP antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 1 second.
	Immunohistochemistry: p97/VCP Antibody [NB100-1558] - Sample: FFPE section of mouse teratoma. Antibody: Affinity purified rabbit anti-expndtw-4 VCP used at a dilution of 1:200 (1ug/ml). Detection: DAB
	Immunohistochemistry: p97/VCP Antibody [NB100-1558] - Sample: FFPE section of human stomach carcinoma. Antibody: Affinity purified rabbit anti-expndtw-4 VCP used at a dilution of 1:200 (1ug/ml). Detection: DAB
	Immunoprecipitation: p97/VCP Antibody [NB100-1558] - Detection of Human and Mouse VCP on HeLa whole cell lysate using NB100-1558. VCP was also immunoprecipitated using rabbit anti-VCP antibodies NB100-1557 and another VCP antibody at 3 mcg/mg lysate.

目次に戻る

Background

Valosin-containing protein (VCP or p97) belongs to the AAA (ATPase associated activities) family and acts as a molecular chaperone to a wide variety of cellular activities. Some of these activities include the alteration of both nuclear and mitotic golgi membranes, ubiquitin-proteasome dependent protein degradation, regulation of the NF-kappa b pathway, and extraction of membrane proteins. VCP has been shown to contain a substrate binding domain (N) and two conserved ATPase domains (D1 and D2). The three dimensional structure of VCP resembles that of a cylinder with the D1 and D2 stacked upon one another in a homo-hexameric ring formation. VCP is involved in the formation of neuronal inclusion bodies in neurodegenerative disease such as Parkinson's Disease.

目次に戻る