抗DNMT3B抗体 | Anti-DNMT3B antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

Sample (30 ug of whole cell lysate) A: Non-transfected 293T lysates  B: DNMT3B transfected 293T lysates 7.5% SDS PAGE GTX125917 diluted at 1:1000

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	1:500-1:3000

Not tested in other applications.

Calculated MW	97 kDa. ( Note )
Positive Control	Recombinant DNMT3B protein
Predict Reactivity	Human, Mouse, Rat, Bovine, Pig(>80% identity)

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PROPERTIES

Form	Liquid
Buffer	1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Mouse
Immunogen	Recombinant protein encompassing a sequence within the C-terminus region of mouse DNMT3B. The exact sequence is proprietary.
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	DNA methyltransferase 3B , MmuIIIB
Cellular Localization	Nucleus
Background	Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
Database	・ Gene ID: 13436 Dnmt3b ・ UniProt: O88509 Dnmt3b

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