抗Human/Mouse CCR6 PE-conjugated抗体(Anti-Human/Mouse CCR6 PE-conjugated antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human, Mouse
Label	Phycoerythrin
Immunogen	RBL-1 rat basophilic leukemia cell line transfected with mouse CCR6Met1-Met367Accession # O54689
Source	Monoclonal Rat IgG2A Clone # 140706
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Detects mouse CCR6-transfected rat RBL cells but not the parent cell line or cells transfected with mouse CCR5. Detects human CCR6 in flow cytometry.

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	10 µL/106 cells	Mouse splenocytes and human peripheral blood lymphocytes

Flow Cytometry
	Detection of CCR6 in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Rat Anti-Mouse B220/CD45R APC‑conjugated Monoclonal Antibody (Catalog # FAB1217A) and either (A) Rat Anti-Human/Mouse CCR6 PE‑conjugated Monoclonal Antibody (Catalog # FAB590P) or (B) Rat IgG2A Phycoerythrin Isotype Control (Catalog # IC006P). View our protocol for Staining Membrane-associated Proteins.
Flow Cytometry
	Detection of CCR6 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD19 APC‑conjugated Monoclonal Antibody (Catalog # FAB4867A) and either (A) Rat Anti-Human/Mouse CCR6 PE‑conjugated Monoclonal Antibody (Catalog # FAB590P) or (B) Rat IgG2A Phycoerythrin Isotype Control (Catalog # IC006P). View our protocol for Staining Membrane-associated Proteins.

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Related Product & Information

Entrez Gene IDs	1235 (Human); 12458 (Mouse); 308163 (Rat)
Background	CCR6
background_content	Background: CCR6 CCR6 is a seven transmembrane-spanning G protein-coupled receptor that binds the chemokine MIP-3 alpha and mediates the chemoattraction of B and T lymphocytes.

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Citations

1. The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages.
   Authors: Boyle S, Faulkner J, McColl S, Kochetkova M
   Mol Cancer, 2015;14(0):115.
   Species: Mouse
   Sample Type: Cell Lysates
   Application: Flow


2. Infection of Female BWF1 Lupus Mice with Malaria Parasite Attenuates B Cell Autoreactivity by Modulating the CXCL12/CXCR4 Axis and Its Downstream Signals PI3K/AKT, NFkappaB and ERK.
   Authors: Badr G, Sayed A, Abdel-Maksoud M, Mohamed A, El-Amir A, Abdel-Ghaffar F, Al-Quraishy S, Mahmoud M
   PLoS ONE, 2015;10(4):e0125340.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


3. Differential developmental requirement and peripheral regulation for dermal Vgamma4 and Vgamma6T17 cells in health and inflammation.
   Authors: Cai Y, Xue F, Fleming C, Yang J, Ding C, Ma Y, Liu M, Zhang H, Zheng J, Xiong N, Yan J
   Nat Commun, 2014;5(0):3986.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


4. Cryptococcus gattii infection dampens Th1 and Th17 responses by attenuating dendritic cell function and pulmonary chemokine expression in the immunocompetent hosts.
   Authors: Angkasekwinai P, Sringkarin N, Supasorn O, Fungkrajai M, Wang Y, Chayakulkeeree M, Ngamskulrungroj P, Angkasekwinai N, Pattanapanyasat K
   Infect Immun, 2014;82(9):3880-90.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


5. Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis.
   Authors: Klein M, Brouwer M, Angele B, Geldhoff M, Marquez G, Varona R, Hacker G, Schmetzer H, Hacker H, Hammerschmidt S, van der Ende A, Pfister H, van de Beek D, Koedel U
   PLoS ONE, 2014;9(4):e93057.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


6. Liver-resident NK cells confer adaptive immunity in skin-contact inflammation.
   Authors: Peng, Hui, Jiang, Xiaojun, Chen, Yonglin, Sojka, Dorothy, Wei, Haiming, Gao, Xiang, Sun, Rui, Yokoyama, Wayne M, Tian, Zhigang
   J Clin Invest, 2013;123(4):1444-56.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


7. Difference in Th1 and Th17 lymphocyte adhesion to endothelium.
   Authors: Alcaide P, Maganto-Garcia E, Newton G, Travers R, Croce KJ, Bu DX, Luscinskas FW, Lichtman AH
   J. Immunol., 2012;188(3):1421-30.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


8. Notch, Id2, and ROR gamma-t sequentially orchestrate the fetal development of lymphoid tissue inducer cells.
   Authors: Cherrier M, Sawa S, Eberl G
   J. Exp. Med., 2012;209(4):729-40.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


9. CCR7-CCL19/CCL21-regulated dendritic cells are responsible for effectiveness of sublingual vaccination.
   Authors: Song JH, Kim JI, Kwon HJ, Shim DH, Parajuli N, Cuburu N, Czerkinsky C, Kweon MN
   J. Immunol., 2009;182(11):6851-60.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


10. ATP drives lamina propria T(H)17 cell differentiation.
    Authors: Atarashi K, Nishimura J, Shima T, Umesaki Y, Yamamoto M, Onoue M, Yagita H, Ishii N, Evans R, Honda K, Takeda K
    Nature, 2008;455(7214):808-12.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Flow

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