抗HGF Receptor/c-MET抗体(Anti-HGF Receptor/c-MET, Phosphorylated, Rabbit-Poly antibody)
掲載日情報:2018/11/26 現在Webページ番号:33284
HGF Receptor/c-METに対する抗体(Anti-HGF Receptor/c-MET, Phosphorylated, Rabbit-Poly )です。
※ 本製品は研究用です。研究用以外には使用できません。
追加しました。
価格
[在庫・価格 :2024年05月18日 00時00分現在]
詳細 | 商品名 |
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文献数 | ||
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Anti-HGF Receptor/c-MET(pTyr1003), Phosphorylated, Rabbit-Poly |
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2 | |||
Anti-Phospho-HGF R/c-MET (Y1003) Affinity Purified PAb |
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1 | |||
[在庫・価格 :2024年05月18日 00時00分現在]
Anti-HGF Receptor/c-MET(pTyr1003), Phosphorylated, Rabbit-Poly
文献数: 2
- 商品コード:AF4059
- メーカー:RSD
- 包装:100μg
- 価格:¥87,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
Anti-Phospho-HGF R/c-MET (Y1003) Affinity Purified PAb
文献数: 1
- 商品コード:AF4059-SP
- メーカー:RSD
- 包装:25μg
- 価格:¥30,000
- 在庫:無(未発注)
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
追加しました。
Product Details
Species Reactivity | Human |
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Label | Unconjugated |
Immunogen | Phosphopeptide containing human HGF R Y1003 site |
Source | Polyclonal Rabbit IgG |
Purification | Antigen Affinity-purified |
Specificity | Detects human and mouse HGF R/c-MET when phosphorylated at Y1003. |
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Applications and Data
Recommended Concentration | Sample | |
Western Blot | 1 µg/mL | See below |
Immunohistochemistry | 5-15 µg/mL | Immersion fixed paraffin-embedded sections of human breast cancer tissue |
Immunocytochemistry | 5-15 µg/mL | See below |
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Related Product & Information
Background | HGF R/c-MET |
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background_content | Background: HGF R/c-MET HGF R, also known as Met (from N-methyl-N’-nitro-N-nitrosoguanidine induced), is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which undergoes cotranslational proteolytic cleavage. This generates a mature HGF R that is a disulfide-linked dimer composed of a 50 kDa extracellular alpha chain and a 145 kDa transmembrane beta chain (1, 2). The extracellular domain (ECD) contains a seven bladed beta -propeller sema domain, a cysteine-rich PSI/MRS, and four Ig-like E-set domains, while the cytoplasmic region includes the tyrosine kinase domain (3, 4). Proteolysis and alternate splicing generate additional forms of human HGF R which either lack of the kinase domain, consist of secreted extracellular domains, or are deficient in proteolytic separation of the alpha and beta chains (5 - 7). The sema domain, which is formed by both the alpha and beta chains of HGF R, mediates both ligand binding and receptor dimerization (3, 8). Ligand-induced tyrosine phosphorylation in the cytoplasmic region activates the kinase domain and provides docking sites for multiple SH2-containing molecules (9, 10). HGF stimulation induces HGF R downregulation via internalization and proteasome-dependent degradation (11). In the absence of ligand, HGF R forms noncovalent complexes with a variety of membrane proteins including CD44v6, CD151, EGF R, Fas, Integrin alpha 6/ beta 4, Plexins B1, 2, 3, and MSP R/Ron (12 - 19). Ligation of one complex component triggers activation of the other, followed by cooperative signaling effects (12 - 19). Formation of some of these heteromeric complexes is a requirement for epithelial cell morphogenesis and tumor cell invasion (12, 16, 17). Paracrine induction of epithelial cell scattering and branching tubulogenesis results from the stimulation of HGF R on undifferentiated epithelium by HGF released from neighboring mesenchymal cells (20). Genetic polymorphisms, chromosomal translocation, overexpression, and additional splicing and proteolytic cleavage of HGF R have been described in a wide range of cancers (1). Within the ECD, human HGF R shares 86% - 88% aa sequence identity with canine, mouse, and rat HGF R. |
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Citations
- Protein signatures for classification and prognosis of gastric cancer a signaling pathway-based approach.
Authors: Wang D, Ye F, Sun Y, Li W, Liu H, Jiang J, Zhang Y, Liu C, Tong W, Gao L, Sun Y, Zhang W, Seetoe T, Lee P, Suo J, Zhang DY
Am. J. Pathol., 2011;179(4):1657-66.
Species: Human
Sample Type: Tissue Homogenates
Application: Protein Array Development
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