抗Nectin-4抗体(Anti-Nectin-4, Mouse-Mono, PE antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Phycoerythrin
Immunogen	Mouse myeloma cell line NS0-derived recombinant human Nectin-4Gly27-Val351Accession # Q96NY8
Source	Monoclonal Mouse IgG2B Clone # 337516
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Detects human Nectin-4 in direct ELISAs and Western blots. In direct ELISAs and Western blots, does not cross-react with recombinant human Nectin‑1, -2, -3, or recombinant mouse Nectin-4.

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	10 µL/106 cells	See below

Flow Cytometry
	Detection of Nectin-4 in MCF-7 Human Cell Line by Flow Cytometry. MCF-7 human breast cancer cell line was stained with Mouse Anti-Human Nectin-4 PE-conjugated Monoclonal Antibody (Catalog # FAB2659P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.

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Related Product & Information

Long Name	Poliovirus Receptor Related 4
Background	Nectin-4
background_content	Background: Nectin-4 Nectin-4 is a type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. It is both a homophilic and heterophilic (with Nectin-1) cell adhesion molecule that is expressed in the embryo and in breast carcinoma. A soluble form of Nectin-4 is generated from the membrane protein via the action of TACE/ADAM-17. The extracellular domain of human Nectin-4 shares 90% and 92% amino acid sequence homology with the corresponding regions of mouse and rat Nectin-4, respectively.

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Citations

1. Measles virus infection of human keratinocytes: Possible link between measles and atopic dermatitis
   Authors: G Gourru-Les, C Mathieu, T Thevenet, V Guillaume-, JF Jégou, CG Boer, K Tomczak, LM Bloyet, C Giraud, S Grande, C Goujon, C Cornu, B Horvat
   J. Dermatol. Sci, 2017;0(0):.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


2. Attenuated, oncolytic, but not wild-type measles virus infection has pleiotropic effects on human neutrophil function.
   Authors: Zhang Y, Patel B, Dey A, Ghorani E, Rai L, Elham M, Castleton AZ, Fielding AK
   J. Immunol., 2012;188(3):1002-10.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


3. Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus.
   Authors: Noyce RS, Bondre DG, Ha MN
   PLoS Pathog., 2011;7(8):e1002240.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow

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