抗LTBP-4抗体(Anti-LTBP-4, Goat-Poly antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Mouse
Label	Unconjugated
Immunogen	Mouse myeloma cell line NS0-derived recombinant mouse Latent TGF‑ beta bp4 isoform 1Ser25-Ala1666 (Arg542-Pro547)Accession # AAI41006
Source	Polyclonal Goat IgG
Purification	Antigen Affinity-purified
Specificity	Detects mouse Latent TGF‑ beta bp4 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) LTBP-1 and rhLTBP-2 is observed.

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Applications and Data

	Recommended Concentration	Sample
Western Blot	0.1 µg/mL	Recombinant Mouse Latent TGF-beta  bp4

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Related Product & Information

Entrez Gene IDs	8425 (Human)
Background	Latent TGF-beta bp4
background_content	Background: Latent TGF-beta bp4 LTBP-4 is a 170 kDa extracellular glycoprotein that belongs to the LTBP/fibrillin family. These proteins contain a conserved pattern of eight cysteine residues (8Cys) and EGF-like domains. Mouse LTBP-4 isoform 1 is synthesized as 1666 amino acid residues and contains 14 EGF-like motifs and three 8Cys, the 3rd of which is responsible for disulfide-association with the latency-linked associated peptide (LAP) of latent TGF-beta 1. LTBP-4 is expressed in multiple tissues and is involved in the assembly, secretion and targeting of latent TGF-beta to sites where it can be activated. Two additional splice isoforms that differ from isoform 1 in residues 60‑150 or 67‑150, have been described. Human and mouse LTBP-4 share 90% amino acid sequence homology.

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Citations

1. Latent TGF-? binding protein 2 and 4 have essential overlapping functions in microfibril development
   Authors: Y Fujikawa, H Yoshida, T Inoue, T Ohbayashi, K Noda, H von Melchn, T Iwasaka, I Shiojima, TO Akama, T Nakamura
   Sci Rep, 2017;7(0):43714.
   Species: Mouse
   Sample Type: Whole Cells
   Application: ICC


2. Fibulin-4 deposition requires EMILIN-1 in the extracellular matrix of osteoblasts
   Authors: A Schiavinat, DR Keene, T Imhof, R Doliana, T Sasaki, G Sengle
   Sci Rep, 2017;7(1):5526.
   Species: Mouse
   Sample Type: Whole Cells
   Application: ICC


3. Latent TGF-beta binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5.
   Authors: Noda K, Dabovic B, Takagi K, Inoue T, Horiguchi M, Hirai M, Fujikawa Y, Akama T, Kusumoto K, Zilberberg L, Sakai L, Koli K, Naitoh M, von Melchner H, Suzuki S, Rifkin D, Nakamura T
   Proc Natl Acad Sci U S A, 2013;110(8):2852-7.
   Species: Mouse
   Sample Type: Whole Tissue
   Application: IHC Not Specified


4. Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation.
   Authors: Hosui A, Kimura A, Yamaji D, Zhu BM, Na R, Hennighausen L
   J. Exp. Med., 2009;206(4):819-31.
   Species: Mouse
   Sample Type: Cell Culture Supernates
   Application: WB

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