抗TGF-β Receptor Ⅰ抗体(Anti-TGF-β Receptor Ⅰ, Rat-Mono antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human, Mouse
Label	Unconjugated
Immunogen	S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse TGF‑ beta  RI/ALK-5Ala21-Glu121Accession # BAA05023
Source	Monoclonal Rat IgG2A Clone # 141231
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Detects human and mouse TGF-beta RI/ALK-5 in Western blots. In direct ELISAs and Western blots, this antibody shows no cross-reactivity with rrMIS RII, rhTGF‑ beta  RII, rhTGF‑ beta  RIIb, or rhTGF‑ beta  RIII.

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Applications and Data

	Recommended Concentration	Sample
Western Blot	1 µg/mL	Recombinant Mouse TGF-beta  RI/ALK‑5 Fc Chimera (Catalog # 587-RI) and Recombinant Human TGF-beta  RI/ALK‑5 Fc Chimera (Catalog # 3025-BR)

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Related Product & Information

Background

TGF-beta RI/ALK-5

background_content

Background: TGF-beta RI/ALK-5 Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70-85 kDa), and Type III (250-350 kDa). The Type III receptor, a proteoglycan that exists in membrane-bound and soluble forms, binds TGF-beta 1, TGF-beta 2, and TGF-beta 3 but does not appear to be involved in signal transduction. The Type II receptor is a membrane-bound serine/threonine kinase that binds TGF-beta 1 and TGF-beta 3 with high affinity and TGF-beta 2 with a much lower affinity. The Type I receptor, originally known as ALK-5 (Activin receptor‑like kinase) is also a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. Current evidence suggests that signal transduction requires the cytoplasmic domains of both the Type I and Type II receptors.

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Citations

1. Beclin 1 regulates neuronal transforming growth factor-beta signaling by mediating recycling of the type I receptor ALK5.
   Authors: O'Brien C, Bonanno L, Zhang H, Wyss-Coray T
   Mol Neurodegener, 2015;10(1):69.
   Species: Mouse
   Sample Type: Whole Cells
   Application: IHC - Fresh


2. Dendritic cell SIRT1-HIF1alpha axis programs the differentiation of CD4+ T cells through IL-12 and TGF-beta1.
   Authors: Liu G, Bi Y, Xue L, Zhang Y, Yang H, Chen X, Lu Y, Zhang Z, Liu H, Wang X, Wang R, Chu Y, Yang R
   Proc Natl Acad Sci U S A, 2015;112(9):E957-65.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


3. Integrin alpha3beta1 potentiates TGFbeta-mediated induction of MMP-9 in immortalized keratinocytes.
   Authors: Lamar JM, Iyer V, DiPersio CM
   J. Invest. Dermatol., 2007;128(3):575-86.
   Species: Mouse
   Sample Type: Cell Lysates
   Application: WB


4. Differential TGFbeta pathway targeting by miR-122 in humans and mice affects liver cancer metastasis.
   Authors: Yin S, Fan Y, Zhang H, Zhao Z, Hao Y, Li J, Sun C, Yang J, Yang Z, Yang X, Lu J, Xi J
   Nat Commun, 0;7(0):11012.
   Species: Human
   Sample Type: Tissue Homogenates
   Application: WB


5. Fibulin-6 regulates pro-fibrotic TGF-beta responses in neonatal mouse ventricular cardiac fibroblasts.
   Authors: Chowdhury A, Hasselbach L, Echtermeyer F, Jyotsana N, Theilmeier G, Herzog C
   Sci Rep, 0;7(0):42725.
   Species: Mouse
   Sample Type: Cell Lysates
   Application: WB

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