抗SR-A1/MSR1抗体(Anti-SR-A1/MSR1, Goat-Poly antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Mouse
Label	Unconjugated
Immunogen	Mouse myeloma cell line NS0-derived recombinant mouse SR-AI/MSRTrp79-Ser454Accession # AAA39747
Source	Polyclonal Goat IgG
Purification	Antigen Affinity-purified
Specificity	Detects mouse SR-A1/MSR in direct ELISAs and Western blots.

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Applications and Data

	Recommended Concentration	Sample
Western Blot	0.1 µg/mL	Recombinant Mouse SR-AI/MSR (Catalog # 1797-MS)
Blockade of Receptor-ligand Interaction	In a functional ELISA, 0.5-2 µg/mL of this antibody will block 50% of the binding of 100 ng/mL of biotinylated AGE‑BSA to immobilized Recombinant Mouse SR-AI/MSR1 (Catalog # 1797-MS) coated at 5 µg/mL (100 µL/well). At 20 µg/mL, this antibody will block >90% of the binding.

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Related Product & Information

Long Name	Macrophage Scavenger Receptor Types I and II
Entrez Gene IDs	4481 (Human); 20288 (Mouse); 25073 (Rat)
Background	SR-AI/MSR
background_content	Background: SR-AI/MSR The scavenger receptor (SR) family comprises a group of functionally defined membrane receptors that share the common ability to bind and internalize modified forms of Low Density Lipoproteins (mLDL) (1 - 3). Family members are classified alphabetically. The A class include four proteins: the three subtypes of SR-A (AI, AII, and AIII) that are generated by alternative splicing of the same gene, and a structurally similar protein named MARCO (4). All A class SRs are multidomain trimeric type II membrane proteins. SR-AI has an N-terminal cytoplasmic domain, a transmembrane domain, a spacer domain, an alpha -helical coiled coil, a collagen-like domain and a C-terminal cysteine-rich domain. SR-A is expressed by most tissue macrophages, dendritic cells and Kupffer cells. It is also highly expressed by microglia in neonatal as well as Alzheimer’ Disease brains. SR-AI binds a broad range of polyanionic ligands including modified proteins (e.g. Oxidized, acetylated or maleylated LDL, Advanced glycation end-product proteins), polyribonucleotides (polyguanosine and polyinosine), polysaccharides (dextran sulfate, fucoidan), phospholipids (phosphatidylserine), bacterial products (lipopolysaccharide and lipoteichoic acid) and selected chemical compounds (silica, crocidolite asbestos). The ligand-binding region has been localized to a positively charged region in the carboxyl end of the collagen-like domain. Based on its ligand binding characteristics, SR-AI is implicated in many physiological and pathophysiological functions. Studies using SR-A knockout mouse have also suggested roles of SR-A in atherogenesis, host defense and innate immunity, acquired immune responses, macrophage adhesion, and phagocytosis of apoptotic cells (1 - 3).

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Citations

1. Effects of scavenger receptors-1 class A stimulation on macrophage morphology and highly modified advanced glycation end product-protein phagocytosis
   Authors: S Hamasaki, T Kobori, Y Yamazaki, A Kitaura, A Niwa, T Nishinaka, M Nishibori, S Mori, S Nakao, H Takahashi
   Sci Rep, 2018;8(1):5901.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Neut


2. Exercise training enhances in vivo clearance of endotoxin and attenuates inflammatory responses by potentiating Kupffer cell phagocytosis
   Authors: S Komine, K Akiyama, E Warabi, S Oh, K Kuga, K Ishige, S Togashi, T Yanagawa, J Shoda
   Sci Rep, 2017;7(1):11977.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


3. Autophagy regulates phagocytosis by modulating the expression of scavenger receptors.
   Authors: Bonilla D, Bhattacharya A, Sha Y, Xu Y, Xiang Q, Kan A, Jagannath C, Komatsu M, Eissa N
   Immunity, 2013;39(3):537-47.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


4. The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis.
   Kidney Int, 2012;82(7):759-70.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Neut


5. CD204 suppresses large heat shock protein-facilitated priming of tumor antigen gp100-specific T cells and chaperone vaccine activity against mouse melanoma.
   Authors: Qian J, Yi H, Guo C, Yu X, Zuo D, Chen X, Kane JM, Repasky EA, Subjeck JR, Wang XY
   J. Immunol., 2011;187(6):2905-14.
   Species: Mouse
   Sample Type: Cell Lysates
   Application: WB


6. Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells.
   Authors: Guimaraes EL, Empsen C, Geerts A, van Grunsven LA
   J. Hepatol., 2010;52(3):389-97.
   Species: Mouse
   Sample Type: Cell Lysates
   Application: WB


7. Cilostazol inhibits modified low-density lipoprotein uptake and foam cell formation in mouse peritoneal macrophages.
   Authors: Okutsu R, Yoshikawa T, Nagasawa M, Hirose Y, Takase H, Mitani K, Okada K, Miyakoda G, Yabuuchi Y
   Atherosclerosis, 2009;204(2):405-11.
   Species: Mouse
   Sample Type: Cell Lysates
   Application: WB


8. Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like receptor 4 signaling-dependent CD8 T-cell activation.
   Authors: Yi H, Yu X, Gao P, Wang Y, Baek SH, Chen X, Kim HL, Subjeck JR, Wang XY
   Blood, 2009;113(23):5819-28.
   Species: Mouse
   Sample Type: Cell Lysates
   Application: WB

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