抗Human TrkB抗体(Anti-Human TrkB antibody)
掲載日情報:2018/11/26 現在Webページ番号:30581
Human TrkBに対する抗体(Anti-Human TrkB )です。
※ 本製品は研究用です。研究用以外には使用できません。
追加しました。
価格
[在庫・価格 :2025年04月27日 00時00分現在]
詳細 | 商品名 |
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文献数 | ||
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Anti-Human TrkB MAb (Clone 72509) |
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1 | |||
Anti-Human TrkB MAb (Clone 72509) |
|
1 | |||
Anti-Human TrkB MAb (Clone 72509) |
|
1 | |||
[在庫・価格 :2025年04月27日 00時00分現在]
Anti-Human TrkB MAb (Clone 72509)
文献数: 1
- 商品コード:MAB3971-100
- メーカー:RSD
- 包装:100μg
- 価格:¥101,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
Anti-Human TrkB MAb (Clone 72509)
文献数: 1
- 商品コード:MAB3971-500
- メーカー:RSD
- 包装:500μg
- 価格:¥232,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
Anti-Human TrkB MAb (Clone 72509)
文献数: 1
- 商品コード:MAB3971-SP
- メーカー:RSD
- 包装:25μg
- 価格:¥30,000
- 在庫:無(未発注)
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
追加しました。
Product Details
Species Reactivity | Human |
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Label | Unconjugated |
Immunogen | Mouse myeloma cell line NS0-derived recombinant human TrkBCys32-His430Accession # Q16620 |
Source | Monoclonal Mouse IgG1 Clone # 72509 |
Purification | Protein A or G purified from hybridoma culture supernatant |
Specificity | Detects human TrkB in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) TrkA, recombinant rat TrkA, recombinant mouse (rm) TrkB, rhTrkC, or rmTrkC is observed. |
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Applications and Data
Recommended Concentration | Sample | |
Flow Cytometry | 0.25 µg/106 cells | Human TrkB transfected C6 cells |
CyTOF-ready | Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation. |
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Related Product & Information
Long Name | Neurotrophic Tyrosine Kinase Receptor B |
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Entrez Gene IDs | 4915 (Human); 18212 (Mouse); 25054 (Rat) |
Background | TrkB |
background_content | Background: TrkB The neurotrophins, including NGF, BDNF, NT-3, and NT-4/5 constitute a group of structurally related, secreted proteins that play an important role in the development and function of the nervous system. The biological activities of the neurotrophins are mediated by binding to the different members of the Trk family tyrosine kinase receptors. Three Trk family proteins, TrkA, TrkB, and TrkC, exhibiting different ligand specificities, have been identified. TrkA binds NGF, TrkB binds BDNF andNT‑4/5 and TrkC binds NT-3. All Trk family proteins share a conserved complex subdomain organization consisting of a signal peptide, two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain. Natural splice variants of the different Trks, including TrkB variants lacking the first cysteine-rich domain, the first and second or all three of the leucine-rich motifs, or the tyrosine kinase domain, have been described. The role of the different extracellular subdomains of TrkB in mediating neurotrophin binding and discrimination is currently being investigated. At the protein sequence level, human and rat TrkB are greater than 90% identical and the proteins exhibit cross-species activity. TrkB is primarily expressed in the nervous system. However, low levels of TrkB expression have also been observed in a wide variety of tissues (pancreas, kidneys, ovary) outside the nervous system. |
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Citations
- P75 neurotrophin receptor is sequestered in the Golgi apparatus of the U-87 MG human glioblastoma cell line.
Authors: Giraud S, Loum E, Bessette B, Mathonnet M, Lalloue F
Int. J. Oncol., 2011;38(2):391-9.
Species: Human
Sample Type: Whole Cells
Application: ICC - BDNF and its receptors in human myasthenic thymus: implications for cell fate in thymic pathology.
Authors: Berzi A, Ayata CK, Cavalcante P, Falcone C, Candiago E, Motta T, Bernasconi P, Hohlfeld R, Mantegazza R, Meinl E, Farina C
J. Neuroimmunol., 2008;197(2):128-39.
Species: Human
Sample Type: Whole Cells
Application: Flow - Brain-derived neurotrophic factor stimulates bone/cementum-related protein gene expression in cementoblasts.
Authors: Kajiya M, Shiba H, Fujita T, Ouhara K, Takeda K, Mizuno N, Kawaguchi H, Kitagawa M, Takata T, Tsuji K, Kurihara H
J. Biol. Chem., 2008;283(23):16259-67.
Species: Human
Sample Type: Whole Cells
Application: ICC
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