抗Angiotensin Converting Enzyme抗体(Anti-Angiotensin Converting Enzyme, Mouse-Mono, PE antibody)
掲載日情報:2018/11/26 現在Webページ番号:30571
Angiotensin Converting Enzymeに対する抗体(Anti-Angiotensin Converting Enzyme, Mouse-Mono, PE )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 :2024年06月19日 18時15分現在]
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Anti-Angiotensin Converting Enzyme, Mouse-Mono(171417), PE <Anti-ACE> <Anti-CD143> |
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[在庫・価格 :2024年06月19日 18時15分現在]
Anti-Angiotensin Converting Enzyme, Mouse-Mono(171417), PE <Anti-ACE> <Anti-CD143>
文献数: 1
- 商品コード:FAB929P
- メーカー:RSD
- 包装:100tests
- 価格:¥77,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 |
別名:ACE1angiotensin converting enzyme クローン:171417 Genbank No: 1636 |
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保存条件 | 4℃,暗所保存 | 法規備考 | |
抗原種 | Human | 免疫動物 | Mouse |
交差性 | Human | 適用 | FCM |
標識 | PE | 性状 | Protein A/G Affinity Purified |
吸収処理 | クラス | IgG | |
クロナリティ | Monoclonal | フォーマット | |
掲載カタログ |
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Product Details
Species Reactivity | Human |
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Label | Phycoerythrin |
Immunogen | Mouse myeloma cell line NS0-derived recombinant human ACE/CD143aa 30-1261 |
Source | Monoclonal Mouse IgG1 Clone # 171417 |
Purification | Protein A or G purified from hybridoma culture supernatant |
Specificity | Detects human ACE/CD143 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human ACE-2 is observed. Detects the surface expression of human ACE on full length ACE transfectants, but not on control transfectants by flow cytometry. |
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Applications and Data
Recommended Concentration | Sample | |
Flow Cytometry | 10 µL/106 cells | See below |
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Related Product & Information
Background | ACE/CD143 |
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background_content | Background: ACE/CD143 ACE (also known as peptidyl-dipetidase A) is a zinc metallopeptidase important for blood pressure control and water and salt metabolism (2). It cleaves the C-terminal dipeptide from angiotensin I to produce the potent vasopressor octapeptide angiotensin II and inactivates bradykinin by the sequential removal of two C-terminal dipeptides. In addition to the two physiological substrates, ACE cleaves C-terminal dipeptides from various oligopeptides with a free C-terminus. Because of its location and specificity, ACE plays additional roles in immunity, reproduction and neuropeptide regulation. For example, ACE degrades Alzheimer amyloid beta -peptide (A beta ), retards A beta aggregation, deposition, fibril formation, and inhibits cytotoxicity (3). ACE is a type I membrane protein and exists in two isoforms (2). Somatic ACE, found in endothelial, epithelial and neuronal cells, comprises two highly similar domains called N- and C-domains, each of which contains the HExxH consensus sequence for zinc binding. Germinal ACE, found exclusively in the testes, comprises a single catalytically active domain identical to the C-domain of somatic ACE except for an N-terminal 67 residue germinal ACE-specific sequence. Physiological functions of the two tissue-specific isozymes are not interchangeable (4). For example, sperm-specific expression of the germinal ACE, not the somatic ACE, in ACE knockout male mice restored fertility. Soluble ACE is present in many biological fluids, such as serum, seminal fluid, amniotic fluid and cerebrospinal fluid (2). The soluble ACE is derived from the membrane forms by actions of secretases or sheddases. The identities of the secretases have not been revealed, although they belong to the family of zinc metallopeptidases (5, 6). |
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Citations
- Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium.
Authors: Pelosi E, Castelli G, Martin-Padura I, Bordoni V, Santoro S, Conigliaro A, Cerio A, De Santis Puzzonia M, Marighetti P, Biffoni M, Alonzi T, Amicone L, Alcalay M, Bertolini F, Testa U, Tripodi M
PLoS ONE, 2012;7(12):e51109.
Species: Human
Sample Type: Whole Cells
Application: Flow
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