抗IL-15 Receptor α抗体(Anti-IL-15 Receptor α, Human, Mouse-Mono antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Unconjugated
Immunogen	S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL‑15 R alpha Ile31-Thr172Accession # EAW86418
Source	Monoclonal Mouse IgG1 Clone # 151307
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Detects human IL-15 R alpha in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse IL‑15 R alpha, recombinant human (rh) IL-2 R alpha, rhIL-2 R beta, or rhIL-2 R gamma is observed.

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Applications and Data

	Recommended Concentration	Sample
Western Blot	1 µg/mL	Recombinant Human IL‑15 R alpha Fc Chimera (Catalog # 147-IR)

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Related Product & Information

Background

IL-15 R alpha

background_content

Background: IL-15 R alpha Interleukin 15 receptor alpha (IL-15 R alpha ) is a high affinity receptor that specifically binds IL-15 with high affinity and associates as a heterotrimer with the IL-2 receptors beta and gamma subunits to initiate signal transduction. IL-15 R alpha is expressed on a wide variety of T cells and B cells as well as non-lymphoid cells.IL‑15 R alpha is a 58-60 kDa protein that shares structural similarities to the IL-2 R alpha protein. IL-15 R alpha and IL-2 R alpha genes also share similar intron-exon organization and are closely linked on human chromosome 10p14-p15. Human IL-15 R alpha shares 45% amino acid (aa) homology with the mouse form of the receptor. Eight isoforms ofIL‑15 R alpha mRNA have been identified resulting from alternative splicing events involving different exons. The exclusion of exon 2 results in an IL-15 R alpha isoform that does not bind IL-15. Human IL-15 R alpha DE3 cDNA encodes a 267 aa protein that contains a 30 aa signal sequence, a 175 aa extracellular region containing one N-linked glycosylation site, a 21 aa transmembrane domain and a 41 aa cytoplasmic tail. Signaling of IL-15 can occur in one of three ways; through the heterotrimeric complex of IL-15 R alpha, IL-2 R beta, and IL-2 R gamma c, through the heterodimeric complex of IL-2 receptors beta and gamma common, through a novel 60-65 kDa IL-15 RX subunit found on mast cells. The binding of IL-15 to IL-15 R alpha has been reported to antagonize the TNF-alpha -mediated apoptosis in fibroblasts by competing with TNF RI for TRAF2 binding.

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Citations

1. A Refractory Celiac Patient Successfully Treated With Mesenchymal Stem Cell Infusions
   Authors: R Ciccociopp, A Gallia, MA Avanzini, E Betti, C Picone, A Vanoli, C Paganini, F Biagi, R Maccario, GR Corazza
   Mayo Clin Proc, 2016;0(0):.
   Species: Human
   Sample Type: BALF
   Application: WB


2. IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers.
   Authors: Marra P, Mathew S, Grigoriadis A, Wu Y, Kyle-Cezar F, Watkins J, Rashid M, De Rinaldis E, Hessey S, Gazinska P, Hayday A, Tutt A
   Cancer Res, 2014;74(17):4908-21.
   Species: Human
   Sample Type: Whole Tissue
   Application: IHC Paraffin-embedded


3. IL-15 Expression on RA Synovial Fibroblasts Promotes B Cell Survival.
   Authors: Benito-Miguel M, Garcia-Carmona Y, Balsa A, Bautista-Caro MB, Arroyo-Villa I, Cobo-Ibanez T, Bonilla-Hernan MG, De Ayala CP, Sanchez-Mateos P, Martin-Mola E, Miranda-Carus ME
   PLoS ONE, 2012;7(7):e40620.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


4. EBV-associated mononucleosis does not induce long-term global deficit in T-cell responsiveness to IL-15.
   Authors: Giron-Michel J, Menard F, Negrini S, Devocelle A, Azzarone B, Besson C
   Blood, 2009;113(19):4541-7.
   Species: Human
   Sample Type: Cell Lysates
   Application: WB


5. Phase I trial of a CD8+ T-cell peptide epitope-based vaccine for infectious mononucleosis.
   Authors: Elliott SL, Suhrbier A, Miles JJ
   J. Virol., 2008;82(3):1448-57.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow

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