抗TIMP-4抗体(Anti-TIMP-4, Human, Goat-Poly antibody)
掲載日情報:2019/10/21 現在Webページ番号:29741
TIMP-4に対する抗体(Anti-TIMP-4, Human, Goat-Poly )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 :2024年05月18日 08時15分現在]
詳細 | 商品名 |
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文献数 | ||
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Anti-TIMP-4, Human, Goat-Poly |
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1 | |||
Anti-Human/Mouse TIMP-4 Affinity Purified Polyclonal Ab |
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0 | |||
[在庫・価格 :2024年05月18日 08時15分現在]
Anti-TIMP-4, Human, Goat-Poly
文献数: 1
- 商品コード:AF974
- メーカー:RSD
- 包装:100μg
- 価格:¥100,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
Anti-Human/Mouse TIMP-4 Affinity Purified Polyclonal Ab
文献数: 0
- 商品コード:AF974-SP
- メーカー:RSD
- 包装:25μg
- 価格:¥30,000
- 在庫:無(未発注)
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
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Product Details
Species Reactivity | Human, Mouse |
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Label | Unconjugated |
Immunogen | Mouse myeloma cell line NS0-derived recombinant human TIMP-4Cys30-Pro224Accession # Q99727 |
Source | Polyclonal Goat IgG |
Purification | Antigen Affinity-purified |
Specificity | Detects human and mouse TIMP‑4 in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant human (rh) TIMP-1, rhTIMP-2, and rhTIMP-3 is observed. In sandwich immunoassays, this antibody is specific for mouse TIMP-4 when paired with the suggested capture antibody. |
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Applications and Data
Recommended Concentration | Sample | |
Western Blot | 0.1 µg/mL | Recombinant Human TIMP‑4 (Catalog # 974-TSF) and Recombinant Mouse TIMP-4 (Catalog # 7667-TM) |
ELISA | This antibody functions as an ELISA detection antibody when paired with Rat Anti-Mouse TIMP‑4 Monoclonal Antibody (Catalog # MAB7667). In sandwich immunoassays, this antibody is specific for mouse TIMP-4 when paired with the suggested capture antibody. This product is intended for assay development on various assay platforms requiring antibody pairs. We recommend the Mouse TIMP-4 DuoSet ELISA Kit (Catalog # DY7667-05) for convenient development of a sandwich ELISA. |
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Related Product & Information
Background | TIMP-4 |
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background_content | Background: TIMP-4 Tissue inhibitors of metalloproteinases (TIMPs) are a family of secreted proteins that regulate the activation and proteolytic activity of the zinc enzymes known as matrix metalloproteinases (MMPs). There are four known members of the family, TIMP-1, -2, -3, and -4. TIMP-4 is produced by a wide range of tissues, particularly brain, heart, ovary and skeletal muscle (1, 2). Limited studies have shown that TIMP-4 has a tumor suppressive effect against Wilm’s tumor, exhibits negative correlation with glioma maligancy and is found in breast carcinoma cells (3‑5). TIMP-4 inhibits MMP-mediated proteolysis by forming a non-covalent binary complex with the MMP active site through its N-terminal domain. In addition, it binds to the hemopexin-like domain of pro-MMP-2 through its C-terminal domain in a manner similar to TIMP-2 (6). However, unlike TIMP-2, TIMP-4 does not promote pro-MMP-2 activation by MT1-MMP (MMP-14) (7). Although TIMP-4 is a potent inhibitor of most MMPs, it is not an effective inhibitor of ADAMs, such as TACE (8, 9). Human TIMP-4 shares 89% sequence indentity with Mouse TIMP-4. |
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Citations
- Effect of bimatoprost, latanoprost, and unoprostone on matrix metalloproteinases and their inhibitors in human ciliary body smooth muscle cells.
Authors: Ooi YH, Oh DJ, Rhee DJ
Invest. Ophthalmol. Vis. Sci., 2009;50(11):5259-65.
Species: Human
Sample Type: Cell Lysates
Application: WB
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