抗DC-SIGN and DC-SIGN2抗体(Anti-DC-SIGN and DC-SIGN2, Human, Mouse-Mono antibody)
掲載日情報：2019/10/21 現在Webページ番号：29529
DC-SIGN and DC-SIGN2に対する抗体(Anti-DC-SIGN and DC-SIGN2, Human, Mouse-Mono )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 ：2024年05月02日 00時00分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
| 詳細 | 商品名 |
|
文献数 | ||
|---|---|---|---|---|---|
|
Anti-DC-SIGN and DC-SIGN2, Human, Mouse-Mono(DC28) <Anti-CD209 and DC-SIGNR> |
|
6 | |||
|
Anti-Human DC-SIGN+DC-SIGNR MAb (Clone DC28) |
|
1 | |||
[在庫・価格 ：2024年05月02日 00時00分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-DC-SIGN and DC-SIGN2, Human, Mouse-Mono(DC28) <Anti-CD209 and DC-SIGNR>
文献数： 6
- 商品コード：MAB16211
- メーカー：RSD
- 包装：500μg
- 価格：¥122,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
Anti-Human DC-SIGN+DC-SIGNR MAb (Clone DC28)
文献数： 1
- 商品コード：MAB16211-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥30,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
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Product Details
| Species Reactivity | Human |
|---|---|
| Label | Unconjugated |
| Immunogen | E. coli-derived recombinant human DC-SIGNExtracellular domain |
| Source | Monoclonal Mouse IgG2A Clone # DC28 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects human DC‑SIGN in direct ELISAs and Western blots. Was reported to cross-react with human DC‑SIGNR as well as DC‑SIGN from Pigtailed Macaque and Rhesus Macaque (10). |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 1 µg/mL | Recombinant Human DC-SIGN Fc Chimera (Catalog # 161-DC) Recombinant Human DC-SIGNR/CD299 Fc Chimera (Catalog # 162-D2) |
| Flow Cytometry | 2.5 µg/106 cells | Human DC‑SIGN transfected 3T3 mouse embryonic fibroblast cell line |
| Adhesion Blockade | The adhesion of NIH-3T3 mouse embryonic fibroblast cells (5 x 104 cells/well) to immobilized Recombinant Human ICAM-3/CD50 Fc Chimera (Catalog # 715-IC, 10 µg/mL, 100 µL/well) was maximally inhibited (80-100%) by 4 µg/mL of the antibody. | |
| CyTOF-ready | Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation. | |
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Related Product & Information
| Long Name | Dendritic Cell-specific ICAM-3-grabbing Non-integrin |
|---|---|
| Entrez Gene IDs | 30835 (Human) |
| Background | DC-SIGN+DC-SIGNR |
| background_content | Background: DC-SIGN+DC-SIGNR DC-SIGN (Dendritic Cell- Specific ICAM-3 Grabbing Non-Integrin) has been shown to play an important role in regulating dendritic cell (DC) and T cell interactions, including antigen presentation to T cells and enhancement of transinfection of CD4+ T cells by HIV-1 (1, 2). Efforts to identify additional type II membrane proteins resulted in the isolation of a molecule related in sequence to DC-SIGN known as DC-SIGNR (DC-SIGN Related) (3, 4). DC-SIGNR shares 73 - 80% amino acid homology with DC-SIGN and is located on human chromosome 19p13.3. Its structure is similar to DC-SIGN and therefore binds mannose residues in a calcium dependent fashion, including ICAM-3 and HIV-1 gp120 (5). DC-SIGNR, also known as L-SIGN (Liver/Lymph node-Specific ICAM-3-Grabbing Non-integrin) and DC‑SIGNR, is polymorphic since allelic variations of the exon 4 encoded sequence have been isolated (5). This is further supported by a study demonstrating the ability to isolate a large repertoire of DC-SIGNR transcripts largely the result of alternative splicing of the 7 coding exons (6). L-SIGN/DC-SIGNR is primarily transcribed in the liver and lymph nodes but not in monocyte derived DC (5). Expression of L-SIGN/DC-SIGNR is restricted to endothelial cells derived from liver sinusoids, lymph nodes sinuses and capillaries (7) although variable expression in placenta and some monocytic cell lines has also been reported, including both membrane and soluble isoforms of the protein (6). Expression of DC-SIGN is induced during the in-vitro generation of DC from either monocytes or bone marrow progenitors, with maximal surface expression at day 7 of culture (1). Immature DC in the skin and mature DC in the tonsil have been demonstrated to express DC‑SIGN (8). Analysis of various tissues and cell lines suggests that DC-SIGN expression is restricted to DC (1) although a more recent report finds evidence of expression in placenta, resting monocytes and monocytic cell lines (6). This discrepancy may be partially related to the multiple isoforms of DC-SIGN transcripts, including both membrane and soluble forms, as well as exon splice variants reported in the latter study (6). A detailed description of the additional properties of this monoclonal antibody may be found in references 9 and 10. |
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Citations
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
- CCR5-, DC-SIGN-dependent endocytosis and delayed reverse transcription after human immunodeficiency virus type 1 infection in human astrocytes.
Authors: Deiva K, Khiati A, Hery C, Salim H, Leclerc P, Horellou P, Tardieu M
AIDS Res. Hum. Retroviruses, 2006;22(11):1152-61.
Species: Human
Sample Type: Whole Cells
Application: Flow
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