抗DC-SIGN/DC-SIGN2抗体(Anti-DC-SIGN/DC-SIGN2, Human, Mouse-Mono, PE antibody)
掲載日情報：2018/11/26 現在Webページ番号：29506
DC-SIGN/DC-SIGN2に対する抗体(Anti-DC-SIGN/DC-SIGN2, Human, Mouse-Mono, PE )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 ：2025年04月26日 20時55分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
| 詳細 | 商品名 |
|
文献数 | ||
|---|---|---|---|---|---|
|
Anti-DC-SIGN/DC-SIGN2, Human, Mouse-Mono(120612), PE |
|
2 | |||
[在庫・価格 ：2025年04月26日 20時55分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-DC-SIGN/DC-SIGN2, Human, Mouse-Mono(120612), PE
文献数： 2
- 商品コード：FAB1621P
- メーカー：RSD
- 包装：100tests
- 価格：¥81,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
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Product Details
| Species Reactivity | Human |
|---|---|
| Label | Phycoerythrin |
| Immunogen | NIH-3T3 mouse embryonic fibroblast cell line transfected with human DC-SIGNRAccession # Q9H2X3 |
| Source | Monoclonal Mouse IgG2A Clone # 120612 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Recognizes both human DC-SIGN and human DC-SIGNR on transfected cells. Does not react with parental mouse cells or irrelevant transfectants. |
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Applications and Data
| Recommended Concentration | Sample | |
| Flow Cytometry | 10 µL/106 cells | See below |
| Flow Cytometry | |
|---|---|
 | Detection of DC‑SIGN+DC‑SIGNR in NIH‑3T3 Mouse Cell Line Transfected with Human DC-SIGN and DC-SIGNR by Flow Cytometry. NIH‑3T3 mouse embryonic fibroblast cell line transfected with (A) human DC-SIGN and (B) human DC-SIGNR was stained with Mouse Anti-Human DC‑SIGN+DC‑SIGNR PE‑conjugated Monoclonal Antibody (Catalog # FAB1621P, filled histogram) or isotype control antibody (Catalog # IC003P, open histogram). View our protocol for Staining Membrane-associated Proteins. |
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Related Product & Information
| Background | DC-SIGN+DC-SIGNR |
|---|---|
| background_content | Background: DC-SIGN+DC-SIGNR DC-SIGN (Dendritic Cell-Specific ICAM-3 Grabbing Non-integrin) has been shown to play an important role in regulating Dendritic Cell (DC) and T cell interactions, including antigen presentation to T cells and enhancement of transinfection of CD4+ T cells by HIV-1 (1, 2). Efforts to identify additional type II membrane proteins resulted in the isolation of a molecule related in sequence to DC-SIGN known as DC-SIGNR (DC-SIGN Related) (3, 4). DC-SIGNR shares 73 - 80% amino acid homology with DC-SIGN and is located on human chromosome 19p13.3. Its structure is similar to DC-SIGN and therefore binds mannose residues in a calcium dependent fashion, including ICAM-3 and HIV-1 gp120 (5). DC-SIGNR, also known as L-SIGN (Liver/Lymph node-Specific ICAM-3-Grabbing Non-integrin) and DC‑SIGNR, is polymorphic since allelic variations of the exon 4 encoded sequence have been isolated (5). This is further supported by a study demonstrating the ability to isolate a large repertoire of DC-SIGNR transcripts largely the result of alternative splicing of the 7 coding exons (6). L-SIGN/DC-SIGNR is primarily transcribed in the liver and lymph nodes but not in monocyte derived DC (5). Expression of L-SIGN/DC-SIGNR is restricted to endothelial cells derived from liver sinusoids, lymph node sinuses and capillaries (7) although variable expression in placenta and some monocytic cell lines has also been reported, including both membrane and soluble isoforms of the protein (6). Expression of DC-SIGN is induced during the in vitro generation of DC from either monocytes or bone marrow progenitors, with maximal surface expression at day 7 of culture (1). Immature DC in the skin and mature DC in the tonsil have been demonstrated to express DC‑SIGN (8). Analysis of various tissues and cell lines suggests that DC-SIGN expression is restricted to DC (1) although a more recent report finds evidence of expression in placenta, resting monocytes and monocytic cell lines (6). This discrepancy may be partially related to the multiple isoforms of DC-SIGN transcripts, including both membrane and soluble forms, as well as exon splice variants reported in the latter study (6). |
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Citations
R&D Systems personnel manually curate a database that contains references using R&D Systems products.
The data collected includes not only links to publications in PubMed,
but also provides information about sample types, species, and experimental conditions.
- Genome-wide small interfering RNA screens reveal VAMP3 as a novel host factor required for Uukuniemi virus late penetration.
Authors: Meier R, Franceschini A, Horvath P, Tetard M, Mancini R, von Mering C, Helenius A, Lozach P
J Virol, 2014;88(15):8565-78.
Species: Human
Sample Type: Whole Cells
Application: Flow
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