抗Human CX3CL1/Fractalkine抗体(Anti-Human CX3CL1/Fractalkine antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Unconjugated
Immunogen	NS0 and E. coli-derived recombinant human CX3CL1/Fractalkine Chemokine DomainGln25-Arg339 (Ser199Asn)Accession # P78423
Source	Monoclonal Mouse IgG1 Clone # 81513
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Detects human CX3CL1/Fractalkine Chemokine Domain in direct ELISAs and Western blots.

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Applications and Data

	Recommended Concentration	Sample
Western Blot	1 µg/mL	Recombinant Human CX3CL1/Fractalkine Full Length (Catalog # 365-FR)
Immunohistochemistry	8-25 µg/mL	Immersion fixed paraffin-embedded sections of human Alzheimer's disease brain

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Related Product & Information

Entrez Gene IDs	6376 (Human); 20312 (Mouse); 89808 (Rat)
Background	CX3CL1/Fractalkine
background_content	Background: CX3CL1/Fractalkine CX3CL1 is a type I membrane protein in which an extracellular chemokine domain possessing a unique C-X3-C cysteine motif is tethered on a long mucin-like stalk. It can also be released as a soluble molecule upon proteolysis at a membrane proximal site.

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Citations

1. Serum level of soluble CX3CL1/fractalkine is elevated in patients with polymyositis and dermatomyositis, which is correlated with disease activity.
   Authors: Suzuki F, Kubota T
   Arthritis Res. Ther., 2012;14(2):R48.
   Species: Human
   Sample Type: Whole Tissue
   Application: IHC Paraffin-embedded


2. Expression of ADAM-17, TIMP-3 and fractalkine in the human adult brain endothelial cell line, hCMEC/D3, following pro-inflammatory cytokine treatment.
   Authors: Hurst LA, Bunning RA, Couraud PO, Romero IA, Weksler BB, Sharrack B, Woodroofe MN
   J. Neuroimmunol., 2009;210(1):108-12.
   Species: Human
   Sample Type: Whole Cells
   Application: ICC


3. Constitutive endocytosis of the chemokine CX3CL1 prevents its degradation by cell surface metalloproteases.
   Authors: Huang YW, Su P, Liu GY, Crow MR, Chaukos D, Yan H, Robinson LA
   J. Biol. Chem., 2009;284(43):29644-53.
   Species: Human
   Sample Type: Whole Cells
   Application: ICC


4. Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migration.
   Authors: Popovic M, Laumonnier Y, Burysek L, Syrovets T, Simmet T
   J. Leukoc. Biol., 2008;84(1):215-23.
   Species: Human
   Sample Type: Cell Lysates
   Application: WB


5. CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis.
   Authors: Truman LA, Ford CA, Pasikowska M, Pound JD, Wilkinson SJ, Dumitriu IE, Melville L, Melrose LA, Ogden CA, Nibbs R, Graham G, Combadiere C, Gregory CD
   Blood, 2008;112(13):5026-36.
   Species: Human
   Sample Type: Cell Lysates
   Application: WB


6. The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma.
   Authors: Marchesi F, Piemonti L, Fedele G, Destro A, Roncalli M, Albarello L, Doglioni C, Anselmo A, Doni A, Bianchi P, Laghi L, Malesci A, Cervo L, Malosio M, Reni M, Zerbi A, Di Carlo V, Mantovani A, Allavena P
   Cancer Res., 2008;68(21):9060-9.
   Species: Human
   Sample Type: Whole Cells
   Application: ICC


7. Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis.
   Authors: Volger OL, Fledderus JO, Kisters N, Fontijn RD, Moerland PD, Kuiper J, van Berkel TJ, Bijnens AP, Daemen MJ, Pannekoek H, Horrevoets AJ
   Am. J. Pathol., 2007;171(1):326-37.
   Species: Human
   Sample Type: Whole Tissue
   Application: IHC

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