抗Mouse TREM-1抗体(Anti-Mouse TREM-1 antibody)
掲載日情報:2019/10/21 現在Webページ番号:29247
Mouse TREM-1に対する抗体(Anti-Mouse TREM-1 )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 :2025年11月03日 13時35分現在]
| 詳細 | 商品名 |
|
文献数 | ||
|---|---|---|---|---|---|
|
Anti-Mouse TREM-1 MAb (Clone 174031) |
|
7 | |||
|
Anti-Mouse TREM-1 MAb (Clone 174031) |
|
7 | |||
|
Anti-Mouse TREM-1 MAb (Clone 174031) |
|
7 | |||
[在庫・価格 :2025年11月03日 13時35分現在]
Anti-Mouse TREM-1 MAb (Clone 174031)
文献数: 7
- 商品コード:MAB1187-100
- メーカー:RSD
- 包装:100μg
- 価格:¥79,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
Anti-Mouse TREM-1 MAb (Clone 174031)
文献数: 7
- 商品コード:MAB1187-500
- メーカー:RSD
- 包装:500μg
- 価格:¥266,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
Anti-Mouse TREM-1 MAb (Clone 174031)
文献数: 7
- 商品コード:MAB1187-SP
- メーカー:RSD
- 包装:25μg
- 価格:¥27,000
- 在庫:1個
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
追加しました。
Product Details
| Species Reactivity | Mouse |
|---|---|
| Label | Unconjugated |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse TREM-1Ala21-Ser202Accession # Q9JKE2 |
| Source | Monoclonal Rat IgG2A Clone # 174031 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects mouse TREM-1 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant mouse TREM-2B, recombinant human (rh) TREM-1, or rhTREM-2 is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 1 µg/mL | Recombinant Mouse TREM‑1 Fc Chimera (Catalog # 1187-TR) |
| Flow Cytometry | 0.25 µg/106 cells | See below |
| Agonist Activity | Measured by its ability to stimulate TNF-alpha secretion by P388D1 mouse lymphoma cells (ATCC # TIB-63). Bouchon, A. et al. (2001) Nature, 410:1103 and Bouchon, A. et al. (2000) J. Immunology, 164:4991. The ED50 for this effect is typically 2-12 μg/mL. | |
| CyTOF-ready | Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation. | |
| Immunocytochemistry | 8-25 µg/mL | See below |
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Related Product & Information
| Long Name | Triggering Receptor Expressed on Myeloid Cells 1 |
|---|---|
| Entrez Gene IDs | 54210 (Human); 58217 (Mouse) |
| Background | TREM-1 |
| background_content | Background: TREM-1 TREM-1 (Triggering Receptor Expressed on Myeloid cells) is a type I transmembrane protein having a single Ig-like domain. It associates with the adapter protein, DAP12, to deliver an activating signal. Several other TREM family members have been reported that are structurally similar but share less than 30% amino acid identity. TREM-1 is expressed on blood neutrophils and a subset of monocytes, and expression is up-regulated by bacterial LPS. Engagement of TREM-1 with a monoclonal antibody leads to expression of IL-8, MCP-1, and TNF-alpha suggesting that this receptor plays an important role in inflammatory responses. TREM-1 is expressed at high levels on neutrophils of patients with microbial sepsis and in mice with LPS-induced shock. Blockade of TREM-1 with a TREM-1/Fc fusion protein protected mice against LPS-induced shock. |
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Citations
- HIV-related proteins prolong macrophage survival through induction of Triggering receptor expressed on myeloid cells-1
Authors: Z Yuan, X Fan, B Staitieh, C Bedi, P Spearman, DM Guidot, RT Sadikot
Sci Rep, 2017;7(0):42028. - TREM-2 promotes macrophage survival and lung disease after respiratory viral infection.
Authors: Wu K, Byers D, Jin X, Agapov E, Alexander-Brett J, Patel A, Cella M, Gilfilan S, Colonna M, Kober D, Brett T, Holtzman M
J Exp Med, 2015;212(5):681-97.
Species: Mouse
Sample Type: Tissue Homogenates
Application: Flow - TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance.
Authors: Weber B, Schuster S, Zysset D, Rihs S, Dickgreber N, Schurch C, Riether C, Siegrist M, Schneider C, Pawelski H, Gurzeler U, Ziltener P, Genitsch V, Tacchini-Cottier F, Ochsenbein A, Hofstetter W, Kopf M, Kaufmann T, Oxenius A, Reith W, Saurer L, Mueller C
PLoS Pathog, 2014;10(1):e1003900.
Species: Mouse
Sample Type: Whole Cells
Application: Functional Assay - Comparison of gene expression profiles between human and mouse monocyte subsets.
Authors: Ingersoll MA, Spanbroek R, Lottaz C
Blood, 2010;115(3):e10-9.
Species: Mouse
Sample Type: Whole Cells
Application: Flow - TREM-1 activation alters the dynamics of pulmonary IRAK-M expression in vivo and improves host defense during pneumococcal pneumonia.
Authors: Lagler H, Sharif O, Haslinger I, Matt U, Stich K, Furtner T, Doninger B, Schmid K, Gattringer R, de Vos AF, Knapp S
J. Immunol., 2009;183(3):2027-36.
Species: Mouse
Sample Type: In Vivo
Application: In vivo
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