抗Human CXCR2/IL-8 RB Fluorescein抗体(Anti-Human CXCR2/IL-8 RB Fluorescein antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Fluorescein
Immunogen	NS0 mouse myeloma cell line transfected with human CXCR2/IL-8 RBMet1-Leu355Accession # AAB25880
Source	Monoclonal Mouse IgG2A Clone # 48311
Purification	Protein A or G purified from ascites
Specificity	Detects human CXCR2/IL-8 RB transfected NS0 cells but not the parental cell line. It does not cross-react with CXCR1 (IL-8 RA).

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	10 µL/106 cells	See below

Flow Cytometry
	Detection of CXCR2/IL-8 RB in Human Peripheral Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Mouse Anti-Human CXCR2/IL-8 RB Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB331F, filled histogram) or isotype control antibody (Catalog # IC003F, open histogram). View our protocol for Staining Membrane-associated Proteins.

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Related Product & Information

Long Name	Interleukin 8 Receptor B
Background	CXCR2/IL-8 RB
background_content	Background: CXCR2/IL-8 RB CXCR2, also known as IL-8 RB, is a G protein-coupled chemokine receptor expressed on neutrophils. It binds IL-8, GRO alpha, GRO beta, GRO gamma, NAP-2, and ENA-78.

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Citations

1. Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals.
   Authors: Hazeldine J, Harris P, Chapple I, Grant M, Greenwood H, Livesey A, Sapey E, Lord J
   Aging Cell, 2014;13(4):690-8.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


2. IL-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs HLA class I-restricted antigen presentation.
   Authors: Morandi, Fabio, Di Carlo, Emma, Ferrone, Soldano, Petretto, Andrea, Pistoia, Vito, Airoldi, Irma
   J Immunol, 2014;192(6):2634-42.
   


3. CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis.
   Authors: Yang G, Rosen DG, Liu G
   Clin. Cancer Res., 2010;16(15):3875-86.
   Species: Human
   Sample Type: Whole Cells
   Application: ICC


4. Enrichment of Foxp3+ CD4 regulatory T cells in migrated T cells to IL-6- and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6.
   Authors: Eikawa S, Ohue Y, Kitaoka K
   J. Immunol., 2010;185(11):6734-40.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


5. HIF-1 and NF-kappaB-mediated upregulation of CXCR1 and CXCR2 expression promotes cell survival in hypoxic prostate cancer cells.
   Authors: Maxwell PJ, Gallagher R, Seaton A, Wilson C, Scullin P, Pettigrew J, Stratford IJ, Williams KJ, Johnston PG, Waugh DJ
   Oncogene, 2007;26(52):7333-45.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


6. Human CXCR2 (hCXCR2) takes over functionalities of its murine homolog in hCXCR2 knockin mice.
   Authors: Mihara K, Smit MJ, Krajnc-Franken M, Gossen J, Rooseboom M, Dokter W
   Eur. J. Immunol., 2005;35(9):2573-82.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow

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