抗TNF Receptor Ⅰ抗体(Anti-TNF Receptor Ⅰ, Human, Mouse-Mono, PE antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Phycoerythrin
Immunogen	E. coli-derived recombinant human TNF RI/TNFRSF1AAccession # NP_001056
Source	Monoclonal Mouse IgG1 Clone # 16803
Purification	Protein A or G purified from ascites
Specificity	Detects human TNF RI in Western blots. In Western blots, does not cross-react with recombinant human TNF RII, recombinant mouse (rm) TNF RI, or rmTNF RII.

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	10 µL/106 cells	See below

Flow Cytometry
	Detection of TNF RI/TNFRSF1A in Human Blood Monocytes by Flow Cytometry. Human peripheral blood monocytes were stained with Mouse Anti-Human TNF RI/TNFRSF1A PE‑conjugated Monoclonal Antibody (Catalog # FAB225P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.

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Related Product & Information

Long Name	Tumor Necrosis Factor Receptor I
Background	TNF RI/TNFRSF1A
background_content	Background: TNF RI/TNFRSF1A TNF RI occurs both in membrane bound and soluble forms and functions as a receptor for TNF-alpha and TNF-beta. In the superfamily nomenclature, it is designated TNFRSF1A.

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Citations

1. Tumour necrosis factor receptor I blockade shows that TNF-dependent and TNF-independent mechanisms synergise in TNF receptor associated periodic syndrome.
   Authors: Fairclough L, Stoop A, Negm O, Radford P, Tighe P, Todd I
   Eur J Immunol, 2015;45(10):2937-44.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


2. TNFR2 and IL-12 coactivation enables slanDCs to support NK-cell function via membrane-bound TNF-alpha.
   Authors: Tufa D, Chatterjee D, Low H, Schmidt R, Jacobs R
   Eur J Immunol, 2014;44(12):3717-28.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


3. TNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-kappaB pathways and signals TRAF2 protein degradation in macrophages.
   Authors: Ruspi G, Schmidt E, McCann F, Feldmann M, Williams R, Stoop A, Dean J
   Cell Signal, 2014;26(4):683-90.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


4. Secretory lysosome targeting and induced secretion of human soluble TNF-alpha receptor in murine hematopoietic cells in vivo as a principle for immunoregulation in inflammation and malignancy.
   Authors: Johansson AC, Nandakumar KS, Persson AM, Olsson I, Hansson M
   Exp. Hematol., 2009;37(8):969-78.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


5. Generation of Th1 and Th2 chemokines by human eosinophils: evidence for a critical role of TNF-alpha.
   Authors: Liu LY, Bates ME, Jarjour NN, Busse WW, Bertics PJ, Kelly EA
   J. Immunol., 2007;179(7):4840-8.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


6. Interaction between transmembrane TNF and TNFR1/2 mediates the activation of monocytes by contact with T cells.
   Authors: Rossol M, Meusch U, Pierer M, Kaltenhauser S, Hantzschel H, Hauschildt S, Wagner U
   J. Immunol., 2007;179(6):4239-48.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


7. Modeling of tumor necrosis factor receptor superfamily 1A mutants associated with tumor necrosis factor receptor-associated periodic syndrome indicates misfolding consistent with abnormal function.
   Authors: Rebelo SL, Bainbridge SE, Amel-Kashipaz MR, Radford PM, Powell RJ, Todd I, Tighe PJ
   Arthritis Rheum., 2006;54(8):2674-87.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


8. Neutrophils from patients with TNFRSF1A mutations display resistance to tumor necrosis factor-induced apoptosis: pathogenetic and clinical implications.
   Authors: D'Osualdo A
   Arthritis Rheum., 2006;54(3):998-1008.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


9. Human cytomegalovirus blocks tumor necrosis factor alpha- and interleukin-1beta-mediated NF-kappaB signaling.
   Authors: Montag C, Wagner J, Gruska I, Hagemeier C
   J. Virol., 2006;80(23):11686-98.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


10. Phagocytosis of codeveloping megakaryocytic progenitors by dendritic cells in culture with thrombopoietin and tumor necrosis factor-alpha and its possible role in hemophagocytic syndrome.
    Authors: Saito K, Hirokawa M, Inaba K, Fukaya H, Kawabata Y, Komatsuda A, Yamashita J, Sawada K
    Blood, 2005;107(4):1366-74.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow

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