抗E-Selectin抗体(Anti-E-Selectin, Human, Mouse-Mono, FITC antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Fluorescein
Source	Monoclonal Mouse IgG1 Clone # BBIG-E5

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry		Please refer to the PDF datasheet for specifications.

Flow Cytometry
	Flow Cytometry Human umbilical cord endothelial cells cultured for 4 hours in the presence of 10 ng/mL of rhTNF-a were stained with anti-human CD62E-Fluorescein (R&D Systems, Cat. # BBA21, filled histogram) or with isotype control (R&D Systems, Cat. # IC002F, open histogram).

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Related Product & Information

Entrez Gene IDs	6401 (Human); 20339 (Mouse); 25544 (Rat)
Background	E-Selectin/CD62E
background_content	Background: E-Selectin/CD62E E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, CD62E) is a 115 kDa type-I membrane glycoprotein expressed only on endothelial cells and only after activation by inflammatory cytokines such as IL-1 beta and TNF-alpha or endotoxin (1 - 4). Expression is transitory reaching a maximum within 6 hours of stimulation and then declining with the generation of a soluble form of E-Selectin (1 - 5). Expression of E-Selectin on cell surfaces facilitates the rolling attachment of leukocytes to the endothelium which is an important step in the extravasation of leukocytes at sites of inflammation (1 - 6). E-Selectin is thought to play a prominent role in inflammatory precesses of the skin (4).

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Citations

1. Bone Morphogenetic Protein 9 Enhances Lipopolysaccharide-Induced Leukocyte Recruitment to the Vascular Endothelium
   J Immunol, 2016;0(0):.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


2. The endocannabinoid/endovanilloid N-arachidonoyl dopamine (NADA) and synthetic cannabinoid WIN55,212-2 abate the inflammatory activation of human endothelial cells.
   Authors: Wilhelmsen K, Khakpour S, Tran A, Sheehan K, Schumacher M, Xu F, Hellman J
   J Biol Chem, 2014;289(19):13079-100.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


3. TWEAK/Fn14 pathway modulates properties of a human microvascular endothelial cell model of blood brain barrier.
   Authors: Stephan D, Sbai O, Wen J, Couraud P, Putterman C, Khrestchatisky M, Desplat-Jego S
   J Neuroinflammation, 2013;10(0):9.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


4. Shear stress modulation of IL-1β-induced E-selectin expression in human endothelial cells.
   Authors: Huang RB, Eniola-Adefeso O
   PLoS ONE, 2012;7(2):e31874.
   Species: Human
   Sample Type: Whole Cells
   Application: ICC


5. ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes.
   Authors: Wilhelmsen K, Mesa K, Lucero J, Xu F, Hellman J
   J Biol Chem, 2012;287(32):26478-94.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


6. Dehydroepiandrosterone inhibits the TNF-alpha-induced inflammatory response in human umbilical vein endothelial cells.
   Authors: Gutierrez G, Mendoza C, Zapata E, Montiel A, Reyes E, Montano LF, Lopez-Marure R
   Atherosclerosis, 2007;190(1):90-9.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


7. Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties.
   Authors: Satchell SC, Anderson KL, Mathieson PW
   J. Am. Soc. Nephrol., 2004;15(3):566-74.
   Species: Human
   Sample Type: Whole Cells
   Application: ICC

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