抗Human NKp30抗体(Anti-Human NKp30 antibody)
掲載日情報:2018/11/26 現在Webページ番号:28631
Human NKp30に対する抗体(Anti-Human NKp30 )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 :2026年04月06日 18時35分現在]
| 詳細 | 商品名 |
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文献数 | ||
|---|---|---|---|---|---|
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Anti-Human NKp30 MAb (Clone 210845) |
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6 | |||
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Anti-Human NKp30 MAb (Clone 210845) |
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6 | |||
|
Anti-Human NKp30 MAb (Clone 210845) |
|
6 | |||
[在庫・価格 :2026年04月06日 18時35分現在]
Anti-Human NKp30 MAb (Clone 210845)
文献数: 6
- 商品コード:MAB1849-100
- メーカー:RSD
- 包装:100μg
- 価格:¥78,000
- 在庫:1個
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
Anti-Human NKp30 MAb (Clone 210845)
文献数: 6
- 商品コード:MAB1849-500
- メーカー:RSD
- 包装:500μg
- 価格:¥259,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
Anti-Human NKp30 MAb (Clone 210845)
文献数: 6
- 商品コード:MAB1849-SP
- メーカー:RSD
- 包装:25μg
- 価格:¥25,000
- 在庫:1個
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
追加しました。
Product Details
| Species Reactivity | Human |
|---|---|
| Label | Unconjugated |
| Immunogen | Mouse T cell hybridoma transfected with human NKp30/NCR3 and Mouse myeloma cell line NS0-derived recombinant human NKp30 Fc Chimera |
| Source | Monoclonal Mouse IgG2A Clone # 210845 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects human NKp30/NCR3 on cell transfectants and peripheral blood NK cells. |
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Applications and Data
| Recommended Concentration | Sample | |
| Flow Cytometry | 2.5 µg/106 cells | Human whole blood CD56+ natural killer cells |
| Agonist Activity | 0.2-1.2 µg/mL | See below |
| CyTOF-ready | Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation. | |
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Related Product & Information
| Entrez Gene IDs | 259197 (Human); 294251 (Rat) |
|---|---|
| Background | NKp30/NCR3 |
| background_content | Background: NKp30/NCR3 NKp30, along with NKp44 and NKp46, constitute a group of receptors termed “Natural Cytotoxicity Receptors” (1). These receptors play a major role in triggering NK‑mediated killing of most tumor cells lines. NKp30 is a type I transmembrane protein having a single extracellular V-like immunoglobulin domain (2). A physical association with the ITAM-bearing accessory protein, CD3 zeta, occurs via a charged residue in the NKp30 transmembrane domain. Ligation of NKp30 with a specific antibody results in phosphorylation of CD3 zeta (3). NKp30 is expressed on both resting and activated NK cells of the CD56dim, CD16+ subset that account for more that 85% of NK cells found in peripheral blood and spleen (4). NKp30 is absent from the CD56bright, CD16- subset that constitutes the majority of NK cells in lymph node and tonsil, however, its expression is up-regulated in these cells upon IL-2 activation (4). Studies with neutralizing antibodies reveal that NKp30 is partially responsible for triggering lytic activity against several tumor cell types and that it is the main receptor responsible for NK‑mediated lysis of immature dendritic cells (2, 5). The ligand(s) recognized by NKp30 has not been described. |
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Citations
- Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and ?? T cells
Authors: Z Djaoud, LA Guethlein, A Horowitz, T Azzi, N Nemat-Gorg, D Olive, D Nadal, PJ Norman, C Münz, P Parham
J. Exp. Med., 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Neut - Homo-oligomerization of the activating natural killer cell receptor NKp30 ectodomain increases its binding affinity for cellular ligands.
Authors: Herrmann, Julia, Berberich, Hannah, Hartmann, Jessica, Beyer, Steffen, Davies, Karen, Koch, Joachim
J Biol Chem, 2014;289(2):765-77.
Species: Human
Sample Type: Whole Cells
Application: Flow - Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma.
Authors: Shi J, Tricot GJ, Garg TK, Malaviarachchi PA, Szmania SM, Kellum RE, Storrie B, Mulder A, Shaughnessy JD, Barlogie B, van Rhee F
Blood, 2007;111(3):1309-17.
Species: Human
Sample Type: Whole Cells
Application: Neut - A novel binding assay to assess specificity of monoclonal antibodies.
Authors: Warren HS, Warren</LastName><ForeNam HS</Initia, Bettadapura J
J. Immunol. Methods, 2005;305(1):33-8.
Species: Human
Sample Type: Complex Sample Type
Application: Epitope Mapping - Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan.
Authors: Warren HS, Jones AL, Freeman C, Bettadapura J, Parish CR
J. Immunol., 2005;175(1):207-12.
Species: Human
Sample Type: Whole Cells
Application: Flow
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