抗Mouse TNF RI/TNFRSF1A抗体(Anti-Mouse TNF RI/TNFRSF1A antibody)
掲載日情報：2019/10/21 現在Webページ番号：28362
Mouse TNF RI/TNFRSF1Aに対する抗体(Anti-Mouse TNF RI/TNFRSF1A )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 ：2026年04月06日 20時55分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
| 詳細 | 商品名 |
|
文献数 | ||
|---|---|---|---|---|---|
|
Anti-Mouse TNF RI/TNFRSF1A MAb (Clone 55R170) |
|
9 | |||
|
Anti-Mouse TNF RI/TNFRSF1A MAb (Clone 55R170) |
|
9 | |||
|
Anti-Mouse TNF RI/TNFRSF1A MAb (Clone 55R170) |
|
9 | |||
[在庫・価格 ：2026年04月06日 20時55分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-Mouse TNF RI/TNFRSF1A MAb (Clone 55R170)
文献数： 9
- 商品コード：MAB430-100
- メーカー：RSD
- 包装：100μg
- 価格：¥83,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
Anti-Mouse TNF RI/TNFRSF1A MAb (Clone 55R170)
文献数： 9
- 商品コード：MAB430-500
- メーカー：RSD
- 包装：500μg
- 価格：¥276,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
Anti-Mouse TNF RI/TNFRSF1A MAb (Clone 55R170)
文献数： 9
- 商品コード：MAB430-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥27,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
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Product Details
| Species Reactivity | Mouse |
|---|---|
| Label | Unconjugated |
| Immunogen | Recombinant mouse TNF RI/TNFRSF1AExtracellular domain |
| Source | Monoclonal Hamster IgG Clone # 55R170 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects mouse TNF RI/TNFRSF1A in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human(rh) 4‑1BB, rhCD27, rhCD30, recombinant mouse (rm) CD27, rmCD30, rhCD40, rmCD40, rhDR3, rhDR6, rmEDAR, rhFas, rmFas, rhEDAR, rhGITR, rmGITR, rhHVEM, rhLT beta R, rmLT beta R, rhNGF R, rhOPG, rmOPG, rhRANK, rmRANK, rhTAJ, rhTNF RI, rhTNF RII or rmTNF RII is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 1 µg/mL | Recombinant Mouse TNF RI/TNFRSF1A (Catalog # 425-R1) under non-reducing conditions only |
| Immunoprecipitation | Sheehan, K. et al. (1995) J. Exp. Med. 181:607. | |
| Neutralization | Measured by its ability to neutralize TNF‑ alpha -induced cytotoxicity in the L‑929 mouse fibroblast cell line. Matthews, N. and M. L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M. J. et al. (eds): IRL Press. 221. The Neutralization Dose (ND50) is typically 5-20 µg/mL in the presence of 0.1 ng/mL Recombinant Mouse TNF‑ alpha and 1 µg/mL actinomycin D. | |
| Neutralization | |
|---|---|
 | Cytotoxicity Induced byTNF‑ alpha and Neutralization by Mouse TNF RI/TNFRSF1A Antibody. Recombinant Mouse TNF‑ alpha (Catalog # 410-MT) induces cytotoxicity in the the L‑929 mouse fibroblast cell line in a dose-dependent manner (orange line). Cytotoxicity elicited by Recombinant Mouse TNF‑ alpha (0.1 ng/mL) is neutralized (green line) by increasing concentrations of Hamster Anti-Mouse TNF RI/TNFRSF1A Monoclonal Antibody (Catalog # MAB430). The ND50 is typically 5-20 µg/mL in the presence of the metabolic inhibitor actinomycin D (1 µg/mL). |
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Related Product & Information
| Long Name | Tumor Necrosis Factor Receptor I |
|---|---|
| Entrez Gene IDs | 7132 (Human); 21937 (Mouse); 25625 (Rat); 102135285 (Cynomolgus Monkey) |
| Background | TNF RI/TNFRSF1A |
| background_content | Background: TNF RI/TNFRSF1A TNF receptor 1 (TNF RI; also called TNF R-p55/p60 and TNFRSF1A) is a type I transmembrane protein member of the TNF receptor superfamily, designated TNFRSF1A (1, 2). Both TNF RI and TNF RII (TNFRSF1B) are widely expressed and contain four TNF-alpha trimer-binding cysteine-rich domains (CRD) in their extracellular domains (ECD). However, TNF RI is thought to mediate most of the cellular effects of TNF-alpha (3). It is essential for proper development of lymph node germinal centers and Peyer’s patches, and for combating intracellular pathogens such as Listeria (1‑3). TNF RI is also a receptor for TNF-beta /TNFSF1B (lymphotoxin-alpha ) (4). TNF RI is present on the cell surface as a trimer of 55 kDa subunits (4, 5). TNF-alpha induces sequestering of TNF RI in lipid rafts, where it activates NF kappa B and is cleaved by ADAM-17/TACE (9, 10). Release of the 28 - 34 kDa TNF RI ECD also occurs constitutively and in response to products of pathogens such as LPS, CpG DNA or S. aureus protein A (1, 6‑8). Full-length TNF RI may also be released in exosome-like vesicles (11). Release helps to resolve inflammatory reactions, since it down-regulates cell surface TNF RI and provides soluble TNF RI to bind TNF-alpha (6, 12, 13). Exclusion from lipid rafts causes endocytosis of TNF RI complexes and induces apoptosis (1). Mouse TNF RI is a 454 amino acid (aa) protein that contains a 21 aa signal sequence, a 191 aa ECD with a PLAD domain (5) that mediates constitutive trimer formation, followed by the four CRD, a 23 aa transmembrane domain, and a 219 aa cytoplasmic sequence that contains a neutral sphingomyelinase activation domain and a death domain (15). The ECD of mouse TNF RI shows 67%, 70%, 64%, 70% and 88% aa identity with canine, feline, porcine, human, and rat TNF RI, respectively; it shows 23% aa identity with the ECD of TNF RII. |
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Citations
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
- Cerebral ischemia-induced angiogenesis is dependent on tumor necrosis factor receptor 1-mediated upregulation of ?5?1 and ?V?3 integrins
J Neuroinflammation, 2016;13(1):227.
Species: Mouse
Sample Type: In Vivo
Application: Neut - Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.
Authors: Wertz I, Newton K, Seshasayee D, Kusam S, Lam C, Zhang J, Popovych N, Helgason E, Schoeffler A, Jeet S, Ramamoorthi N, Kategaya L, Newman R, Horikawa K, Dugger D, Sandoval W, Mukund S, Zindal A, Martin F, Quan C, Tom J, Fairbrother W, Townsend M, Warming S, DeVoss J, Liu J, Dueber E, Caplazi P, Lee W, Goodnow C, Balazs M, Yu K, Kolumam G, Dixit V
Nature, 2015;528(7582):370-5.
Species: Mouse
Sample Type: Cell Lysates
Application: WB - TLR-mediated secretion of endoplasmic reticulum aminopeptidase 1 from macrophages.
Authors: Goto Y, Ogawa K, Nakamura T, Hattori A, Tsujimoto M
J Immunol, 2014;192(9):4443-52.
Species: Mouse
Sample Type: Whole Cells
Application: Neut - Lipopolysaccharide triggered TNF-alpha-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model.
Authors: Kudo H, Takahara T, Yata Y, Kawai K, Zhang W, Sugiyama T
J. Hepatol., 2009;51(1):168-75.
Species: Mouse
Sample Type: In Vivo
Application: In vivo - Hypoxia enhances lysosomal TNF-alpha degradation in mouse peritoneal macrophages.
Authors: Lahat N, Rahat MA, Kinarty A, Weiss-Cerem L, Pinchevski S, Bitterman H
Am. J. Physiol., Cell Physiol., 2008;295(1):C2-12.
Species: Mouse
Sample Type: Cell Lysates
Application: IP - TLR-2 is upregulated and mobilized to the hepatocyte plasma membrane in the space of Disse and to the Kupffer cells TLR-4 dependently during acute endotoxemia in mice.
Authors: Ojaniemi M, Liljeroos M, Harju K, Sormunen R, Vuolteenaho R, Hallman M
Immunol. Lett., 2005;102(2):158-68.
Species: Mouse
Sample Type: In Vivo
Application: In vivo
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