抗Mer抗体(Anti-Mer, Mouse, Goat-Poly, Biotin antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Mouse
Label	Biotin
Immunogen	S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse MerGlu23-Phe498Accession # Q60805
Source	Polyclonal Goat IgG
Purification	Antigen Affinity-purified
Specificity	Detects mouse Mer in Western blots. In Western blots, no cross-reactivity with recombinant mouse (rm) Axl and rmDtk is observed.

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Applications and Data

	Recommended Concentration	Sample
Western Blot	0.1 µg/mL	Recombinant Mouse Mer Fc Chimera (Catalog # 591-MR)
Flow Cytometry	0.25 µg/106 cells	See below

Flow Cytometry

Detection of Mer in J774A.1 Mouse Cell line by Flow Cytometry. J774A.1 mouse reticulum cell sarcoma macrophage cell line was stained with Goat Anti-Mouse Mer Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # BAF591, filled histogram) or isotype control antibody (Catalog # BAF108, open histogram), followed by Streptavidin-Allophycocyanin (Catalog # F0050). View our protocol for Staining Membrane-associated Proteins.

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Related Product & Information

Background

Mer

background_content

Background: Mer Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions (1, 2).

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Citations

1. Conventional DCs from Male and Female Lupus-Prone B6.NZM Sle1/Sle2/Sle3 Mice Express an IFN Signature and Have a Higher Immunometabolism That Are Enhanced by Estrogen
   Authors: MH Lee, M Chakhtoura, U Sriram, R Caricchio, S Gallucci
   J Immunol Res, 2018;2018(0):1601079.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


2. Interferon induced protein 35 exacerbates H5N1 influenza disease through the expression of IL-12p40 homodimer
   Authors: AP Gounder, CC Yokoyama, NN Jarjour, TL Bricker, BT Edelson, ACM Boon
   PLoS Pathog., 2018;14(4):e1007001.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


3. Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis
   Authors: Y Yanagihash, K Segawa, R Maeda, YI Nabeshima, S Nagata
   Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):.
   Species: Mouse
   Sample Type: Cell Lysates
   Application: WB


4. A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present
   Authors: J Sheng, Q Chen, I Soncin, SL Ng, K Karjalaine, C Ruedl
   Cell Rep, 2017;21(5):1203-1214.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


5. Pivotal role for skin trans-endothelial radio-resistant anti-inflammatory macrophages in tissue repair
   Authors: Olga Barreiro
   Elife, 2016;5(0):.
   Species: Mouse
   Sample Type: Tissue Homogenates
   Application: Flow


6. Lymph-borne CD8alpha+ dendritic cells are uniquely able to cross-prime CD8+ T cells with antigen acquired from intestinal epithelial cells.
   Authors: Cerovic V, Houston S, Westlund J, Utriainen L, Davison E, Scott C, Bain C, Joeris T, Agace W, Kroczek R, Mowat A, Yrlid U, Milling S
   Mucosal Immunol, 2015;8(1):38-48.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


7. DNA-Mediated Cyclic GMP-AMP Synthase-Dependent and -Independent Regulation of Innate Immune Responses.
   Authors: Motani K, Ito S, Nagata S
   J Immunol, 2015;194(10):4914-23.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


8. MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands.
   Authors: Toda S, Segawa K, Nagata S
   Blood, 2014;123(25):3963-71.
   Species: Mouse
   Sample Type: Whole Cells
   Application: FACS sorting


9. Distinct development and functions of resident and recruited liver Kupffer cells/macrophages.
   Authors: Ikarashi M, Nakashima H, Kinoshita M, Sato A, Nakashima M, Miyazaki H, Nishiyama K, Yamamoto J, Seki S
   J Leukoc Biol, 2013;94(6):1325-36.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


10. The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung.
    Authors: Fujimori T, Grabiec A, Kaur M, Bell T, Fujino N, Cook P, Svedberg F, MacDonald A, Maciewicz R, Singh D, Hussell T
    Mucosal Immunol, 0;8(5):1021-30.
    Species: Mouse
    Sample Type: BALF
    Application: Flow

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