抗IL-15 Receptor α抗体(Anti-IL-15 Receptor α, Mouse, Goat-Poly, Biotin antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

目次に戻る

Product Details

Species Reactivity	Mouse
Label	Biotin
Immunogen	Mouse myeloma cell line NS0-derived recombinant mouse IL-15 R alpha Gly33-Lys205Accession # Q60819
Source	Polyclonal Goat IgG
Purification	Antigen Affinity-purified
Specificity	Detects mouse IL-15 R alpha in Western blots. In Western blots, approximately 10% cross-reactivity with recombinant human (rh) IL‑15 R alpha is observed and less than 1% cross-reactivity with rhIL-2 R alpha, recombinant mouse (rm) IL-2 R beta, and rmIL-2 R gamma is observed.

目次に戻る

Applications and Data

	Recommended Concentration	Sample
Western Blot	0.1 µg/mL	Recombinant Mouse IL‑15 R alpha Fc Chimera (Catalog # 551-MR)
Flow Cytometry	2.5 µg/106 cells	EL‑4 mouse lymphoblast cell line

目次に戻る

Related Product & Information

Background

IL-15 R alpha

background_content

Background: IL-15 R alpha Interleukin 15 receptor alpha (IL-15 R alpha ) is a high affinity receptor that specifically binds IL-15 with high affinity and associates as a heterotrimer with the IL-2 receptors beta and gamma subunits to initiate signal transduction. IL-15 R alpha is expressed on a wide variety of T cells and B cells as well as non-lymphoid cells. IL‑15 R alpha is a 58-60 kDa protein that shares structural similarities to the IL-2 R alpha protein. IL-15 R alpha and IL-2 R alpha genes also share similar intron-exon organization and are closely linked on human chromosome 10p14-p15. Human IL-15 R alpha shares 45% amino acid (aa) homology with the mouse form of the receptor. Signaling of IL‑15 can occur in one of three ways; through the heterotrimeric complex of IL-15 R alpha, IL-2 R beta, and IL-2 R gamma c, through the heterodimeric complex of IL-2 receptors beta and gamma common, through a novel 60-65 kDa IL-15 RX subunit found on mast cells. The binding of IL-15 to IL-15 R alpha has been reported to antagonize the TNF‑ alpha -mediated apoptosis in fibroblasts by competing with TNF RI for TRAF2 binding.

目次に戻る

Citations

1. IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopenia
   Cell Biosci, 2016;6(0):30.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


2. IL-15 receptor alpha signaling constrains the development of IL-17-producing gammadelta T cells.
   Authors: Colpitts S, Puddington L, Lefrancois L
   Proc Natl Acad Sci U S A, 2015;112(31):9692-7.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


3. Different NK cell developmental events require different levels of IL-15 trans-presentation.
   Authors: Lee GA, Liou YH, Wang SW, Ko KL, Jiang ST, Liao NS
   J. Immunol., 2011;187(3):1212-21.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


4. Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15R alpha.
   Authors: Sato N, Sabzevari H, Fu S, Ju W, Petrus MN, Bamford RN, Waldmann TA, Tagaya Y
   Blood, 2011;117(15):4032-40.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


5. IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity.
   Authors: Sikora AG, Jaffarzad N, Hailemichael Y, Gelbard A, Stonier SW, Schluns KS, Frasca L, Lou Y, Liu C, Andersson HA, Hwu P, Overwijk WW
   J. Immunol., 2009;182(12):7398-407.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


6. Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer.
   Authors: Zhang M, Yao Z, Dubois S, Ju W, Muller JR, Waldmann TA
   Proc. Natl. Acad. Sci. U.S.A., 2009;106(18):7513-8.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


7. A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interaction.
   Authors: Sabatos CA, Doh J, Chakravarti S, Friedman RS, Pandurangi PG, Tooley AJ, Krummel MF
   Immunity, 2008;29(2):238-48.
   Species: Mouse
   Sample Type: Whole Cells
   Application: ICC


8. IL-15 does not affect IEL development in the thymus but regulates homeostasis of putative precursors and mature CD8 alpha alpha+ IELs in the intestine.
   Authors: Lai YG, Hou MS, Hsu YW, Chang CL, Liou YH, Tsai MH, Lee F, Liao NS
   J. Immunol., 2008;180(6):3757-65.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


9. IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development.
   Authors: Vang KB, Yang J, Mahmud SA, Burchill MA, Vegoe AL, Farrar MA
   J. Immunol., 2008;181(5):3285-90.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


10. Antigen controls IL-7Ralpha expression levels on CD8 T cells during full activation or tolerance induction.
    Authors: Hammerbeck CD, Mescher MF
    J. Immunol., 2008;180(4):2107-16.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Functional Assay

目次に戻る